GeneralizedDTA: combining pre-training and multi-task learning to predict drug-target binding affinity for unknown drug discovery

被引：0
|
作者：
Shaofu Lin
Chengyu Shi
Jianhui Chen
机构：
[1] Beijing University of Technology,Faculty of Information Technology
[2] Beijing University of Technology,Beijing International Collaboration Base on Brain Informatics and Wisdom Services
[3] Beijing University Of Technology,Beijing Key Laboratory of MRI and Brain Informatics
来源：
BMC Bioinformatics | / 23卷
关键词：
DTA prediction; Pre-training task; Multi-task learning; Dual adaptation mechanism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] GraphCL-DTA: A Graph Contrastive Learning With Molecular Semantics for Drug-Target Binding Affinity Prediction
    Yang, Xinxing
    Yang, Genke
    Chu, Jian
    IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2024, 28 (08) : 4544 - 4552
  • [42] NerLTR-DTA: drug-target binding affinity prediction based on neighbor relationship and learning to rank
    Ru, Xiaoqing
    Ye, Xiucai
    Sakurai, Tetsuya
    Zou, Quan
    BIOINFORMATICS, 2022, 38 (07) : 1964 - 1971
  • [43] Binding affinity prediction for binary drug-target interactions using semi-supervised transfer learning
    Tanoori, Betsabeh
    Zolghadri Jahromi, Mansoor
    Mansoori, Eghbal G.
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2021, 35 (08) : 883 - 900
  • [44] AttentionDTA: Drug-Target Binding Affinity Prediction by Sequence-Based Deep Learning With Attention Mechanism
    Zhao, Qichang
    Duan, Guihua
    Yang, Mengyun
    Cheng, Zhongjian
    Li, Yaohang
    Wang, Jianxin
    IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2023, 20 (02) : 852 - 863
  • [45] Drug-target binding affinity prediction using message passing neural network and self supervised learning
    Leiming Xia
    Lei Xu
    Shourun Pan
    Dongjiang Niu
    Beiyi Zhang
    Zhen Li
    BMC Genomics, 24
  • [46] Enhancing Drug-Target Binding Affinity Prediction through Deep Learning and Protein Secondary Structure Integration
    Zhang, Runhua
    Zhu, Baozhong
    Jiang, Tengsheng
    Cui, Zhiming
    Wu, Hongjie
    CURRENT BIOINFORMATICS, 2024, 19 (10) : 943 - 952
  • [47] Multidta: drug-target binding affinity prediction via representation learning and graph convolutional neural networks
    Deng, Jiejin
    Zhang, Yijia
    Pan, Yaohua
    Li, Xiaobo
    Lu, Mingyu
    INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS, 2024, 15 (07) : 2709 - 2718
  • [48] Self-Supervised Learning and Multi-Task Pre-Training Based Single-Channel Acoustic Denoising
    Li, Yi
    Sun, Yang
    Naqvi, Syed Mohsen
    2022 IEEE INTERNATIONAL CONFERENCE ON MULTISENSOR FUSION AND INTEGRATION FOR INTELLIGENT SYSTEMS (MFI), 2022,
  • [49] Improving Transformer-based Speech Recognition with Unsupervised Pre-training and Multi-task Semantic Knowledge Learning
    Li, Song
    Li, Lin
    Hong, Qingyang
    Liu, Lingling
    INTERSPEECH 2020, 2020, : 5006 - 5010
  • [50] Multi-target drug repositioning by bipartite block-wise sparse multi-task learning
    Li, Limin
    He, Xiao
    Borgwardt, Karsten
    BMC SYSTEMS BIOLOGY, 2018, 12
12345