Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

被引:0
|
作者
Joseph Bondy-Denomy
Bianca Garcia
Scott Strum
Mingjian Du
MaryClare F. Rollins
Yurima Hidalgo-Reyes
Blake Wiedenheft
Karen L. Maxwell
Alan R. Davidson
机构
[1] University of Toronto,Department of Molecular Genetics
[2] University of Toronto,Department of Biochemistry
[3] Montana State University,Department of Microbiology and Immunology
[4] Donnelly Centre for Cellular and Biomolecular Research,undefined
[5] University of Toronto,undefined
[6] †Present address: Department of Microbiology and Immunology,undefined
[7] University of California,undefined
[8] San Francisco,undefined
[9] San Francisco,undefined
[10] California 94158,undefined
[11] USA.,undefined
来源
Nature | 2015年 / 526卷
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摘要
Bacterial cells evolved an immune system known as CRISPR–Cas to protect themselves from viral infection, triggering viruses to evolve anti-CRISPR proteins; here, three anti-CRISPR proteins are characterized, with each one interfering with the host CRISPR system at a different point.
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页码:136 / 139
页数:3
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