Antimicrobial evaluation of 1,4-benzoxazine derivatives

被引：0
|
作者：
Muralidhar Pamerla
D. Rama Sekhara Reddy
B. Sreenivasa Rao
Naganjaneyulu Bodipati
Y. L. N. Murthy
机构：
[1] GITAM University,Department of Chemistry, Faculty of Sciences
[2] Krishna University,Department of Chemistry, Faculty of Sciences
[3] Andhra University,Department of Chemistry, Faculty of Sciences
来源：
Medicinal Chemistry Research | 2015年 / 24卷
关键词：
Benzoxazine; Antibacterial; Disc diffusion method; Minimum inhibitory concentration; In vitro;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, a series of N-unprotected 1,4-benzoxazine derivatives were evaluated for antibacterial activity. All the compounds showed low to good activity against Gram-positive and Gram-negative bacteria. Benzoxazine derivatives bearing nitro and trifluoromethyl groups are more potent than the other ones. Compounds with cyanide and ester groups have displayed poor activity. The compound 1c has shown good activity against Gram-positive as well as Gram-negative bacteria.
引用
收藏
页码：611 / 615
页数：4
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