SYNTHESIS OF MULTI-SUBSTITUTED 1,4-BENZOXAZINE USING AN UMPOLUNG REACTION WITH 2-OXO-1,4-BENZOXAZINE-3-CARBOXYLATES

被引：8

作者：

Tanaka, Takanori ^{[1
]}

Mizota, Isao ^{[1
]}

Umezu, Kazuto ^{[2
]}

Ito, Akinori ^{[2
]}

Shimizu, Makoto ^{[1
]}

机构：

[1] Mie Univ, Dept Chem Mat, Grad Sch Engn, Tsu, Mie 5148507, Japan

[2] Ihara Chem Ind Co Ltd, Taito Ku, 4-26 Ikenohata 1 Chome, Tokyo 1100008, Japan

来源：

HETEROCYCLES | 2017年 / 95卷 / 02期

关键词：

1,4-Benzoxazine; Organozinc Reagent; N; C-Dialkylation Reaction; Umpolung Reaction; Ketene Silyl Acetal; ALPHA-IMINO ESTERS; TANDEM N-ALKYLATION; AMINO-ACIDS; IMINOESTERS; DERIVATIVES; ALLYLATION; ADDITIONS; REAGENTS; ARYL; SALT;

D O I：

10.3987/COM-16-S(S)52

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes a one-pot synthesis of multi-substituted 1,4-benzoxazine derivatives by atom economical N,C-dialkylation reaction of 1,4-benzoxazine derivatives with various organozinc reagents and ketene silyl acetals (KSA).

引用

页码：830 / 843

页数：14

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