SYNTHESIS OF MULTI-SUBSTITUTED 1,4-BENZOXAZINE USING AN UMPOLUNG REACTION WITH 2-OXO-1,4-BENZOXAZINE-3-CARBOXYLATES

被引：8
|
作者：
Tanaka, Takanori [1 ]
Mizota, Isao [1 ]
Umezu, Kazuto [2 ]
Ito, Akinori [2 ]
Shimizu, Makoto [1 ]
机构：
[1] Mie Univ, Dept Chem Mat, Grad Sch Engn, Tsu, Mie 5148507, Japan
[2] Ihara Chem Ind Co Ltd, Taito Ku, 4-26 Ikenohata 1 Chome, Tokyo 1100008, Japan
来源：
HETEROCYCLES | 2017年 / 95卷 / 02期
关键词：
1,4-Benzoxazine; Organozinc Reagent; N; C-Dialkylation Reaction; Umpolung Reaction; Ketene Silyl Acetal; ALPHA-IMINO ESTERS; TANDEM N-ALKYLATION; AMINO-ACIDS; IMINOESTERS; DERIVATIVES; ALLYLATION; ADDITIONS; REAGENTS; ARYL; SALT;
D O I：
10.3987/COM-16-S(S)52
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This report describes a one-pot synthesis of multi-substituted 1,4-benzoxazine derivatives by atom economical N,C-dialkylation reaction of 1,4-benzoxazine derivatives with various organozinc reagents and ketene silyl acetals (KSA).
引用
收藏
页码：830 / 843
页数：14
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