A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

被引：0

作者：

Kari A Sweeney

Dee N Dao

Michael F Goldberg

Tsungda Hsu

Manjunatha M Venkataswamy

Marcela Henao-Tamayo

Diane Ordway

Rani S Sellers

Paras Jain

Bing Chen

Mei Chen

John Kim

Regy Lukose

John Chan

Ian M Orme

Steven A Porcelli

William R Jacobs

机构：

[1] Howard Hughes Medical Institute,Department of Microbiology and Immunology

[2] Albert Einstein College of Medicine,Department of Microbiology

[3] Albert Einstein College of Medicine,Department of Pathology

[4] Immunology and Pathology,Department of Medicine

[5] Colorado State University,undefined

[6] Albert Einstein College of Medicine,undefined

[7] Albert Einstein College of Medicine,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now report that an attenuated strain of Mycobacterium smegmatis expressing the esx-3 genes from Mtb induces effective CD4+ T cell dependent immunity against infection with Mtb in mice. The study offers a new avenue for the identification of protective immunogens in Mtb infection and a candidate vaccine platform warranting further study.

引用

页码：1261 / 1268

页数：7

共 50 条

[31] Natural and trained innate immunity against Mycobacterium tuberculosis
Ferluga, Janez
Yasmin, Hadida
Al-Ahdal, Mohammed N.
Bhakta, Sanjib
Kishore, Uday
[J]. IMMUNOBIOLOGY, 2020, 225 (03)
[32] Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens
Brodin, P
Majlessi, L
Brosch, R
Smith, D
Bancroft, G
Clark, S
Williams, A
Leclerc, C
Cole, ST
[J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (01): : 115 - 122
[33] Rv0901 from Mycobacterium tuberculosis, a Possible Novel Virulent Gene Proved through the Recombinant Mycobacterium smegmatis
Zhang, Le
Zhong, Qi
Bao, Lang
Zhang, Ying
Gao, Lei
Huang, Bi
Zhang, Hui-Dong
[J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2009, 62 (01) : 26 - 31
[34] Recombinant HBHA Boosting Effect on BCG-Induced Immunity against Mycobacterium tuberculosis Infection
Guerrero, G. G.
Locht, C.
[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,
[35] Mycobacterium smegmatis:: an absurd model for tuberculosis?: Response
Barry, CE
[J]. TRENDS IN MICROBIOLOGY, 2001, 9 (10) : 473 - 474
[36] COMPARISON OF BACTERIOSTATIC AND BACTERICIDAL ACTIVITY OF ISONIAZID AND ETHIONAMIDE AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS
HEIFETS, LB
LINDHOLMLEVY, PJ
FLORY, M
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 143 (02): : 268 - 270
[37] Proteoliposomes from Mycobacterium smegmatis induce immune cross-reactivity against Mycobacterium tuberculosis antigens in mice
Rodriguez, Lissete
Tirado, Yanelys
Reyes, Fatima
Puig, Alina
Kadir, Ramlah
Borrero, Reinier
Fernandez, Sonsire
Reyes, Giselle
Alvarez, Nadine
Garcia, Maria Angeles
Sarmiento, Maria Elena
Norazmi, Mohd Nor
Quinoy, Jose Luis Perez
Acosta, Armando
[J]. VACCINE, 2011, 29 (37) : 6236 - 6241
[38] BACTERIOSTATIC AND BACTERICIDAL ACTIVITY OF CIPROFLOXACIN AND OFLOXACIN AGAINST MYCOBACTERIUM-TUBERCULOSIS AND MYCOBACTERIUM-AVIUM COMPLEX
HEIFETS, LB
LINDHOLMLEVY, PJ
[J]. TUBERCLE, 1987, 68 (04): : 267 - 276
[39] Molecular basis of clarithromycin activity against Mycobacterium avium and Mycobacterium smegmatis
Doucet-Populaire, F
Capobianco, JO
Zakula, D
Jarlier, V
Goldman, RC
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (02) : 179 - 187
[40] Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis
Felix, Carolina Rodrigues
Roberts, Jill C.
Winder, Priscilla L.
Gupta, Rashmi
Diaz, M. Cristina
Pomponi, Shirley A.
Wright, Amy E.
Rohde, Kyle H.
[J]. MARINE DRUGS, 2019, 17 (12)

← 1 2 3 4 5 →