A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

被引：0

作者：

Kari A Sweeney

Dee N Dao

Michael F Goldberg

Tsungda Hsu

Manjunatha M Venkataswamy

Marcela Henao-Tamayo

Diane Ordway

Rani S Sellers

Paras Jain

Bing Chen

Mei Chen

John Kim

Regy Lukose

John Chan

Ian M Orme

Steven A Porcelli

William R Jacobs

机构：

[1] Howard Hughes Medical Institute,Department of Microbiology and Immunology

[2] Albert Einstein College of Medicine,Department of Microbiology

[3] Albert Einstein College of Medicine,Department of Pathology

[4] Immunology and Pathology,Department of Medicine

[5] Colorado State University,undefined

[6] Albert Einstein College of Medicine,undefined

[7] Albert Einstein College of Medicine,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now report that an attenuated strain of Mycobacterium smegmatis expressing the esx-3 genes from Mtb induces effective CD4+ T cell dependent immunity against infection with Mtb in mice. The study offers a new avenue for the identification of protective immunogens in Mtb infection and a candidate vaccine platform warranting further study.

引用

页码：1261 / 1268

页数：7

共 50 条

[21] Involvement of the Mycobacterium tuberculosis secreted antigen SA-5K in intracellular survival of recombinant Mycobacterium smegmatis
Batoni, G
Bottai, D
Maisetta, G
Pardini, M
Boschi, A
Florio, W
Esin, S
Campa, M
[J]. FEMS MICROBIOLOGY LETTERS, 2001, 205 (01) : 125 - 129
[22] Recombinant Mycobacterium smegmatis Expressing an ESAT6-CFP10 Fusion Protein Induces Anti-Mycobacterial Immune Responses and Protects Against Mycobacterium tuberculosis Challenge in Mice
Zhang, H.
Peng, P.
Miao, S.
Zhao, Y.
Mao, F.
Wang, L.
Bai, Y.
Xu, Z.
Wei, S.
Shi, C.
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 72 (04) : 349 - 357
[23] In vitro bactericidal activity of oxazolidinone, RBx 8700 against Mycobacterium tuberculosis and Mycobacterium avium complex
Rao, M.
Sood, R.
Malhotra, S.
Fatma, T.
Upadhyay, D. J.
Rattan, A.
[J]. JOURNAL OF CHEMOTHERAPY, 2006, 18 (02) : 144 - 150
[24] BACTERICIDAL ACTIVITY INVITRO OF VARIOUS RIFAMYCINS AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS
HEIFETS, LB
LINDHOLMLEVY, PJ
FLORY, MA
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03): : 626 - 630
[25] Effects of clofazimine on planktonic and biofilm growth of Mycobacterium tuberculosis and Mycobacterium smegmatis
Mothiba, Maborwa T.
Anderson, Ronald
Fourie, Bernard
Germishuizen, Willem A.
Cholo, Moloko C.
[J]. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2015, 3 (01) : 13 - 18
[26] Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors
Altaf, Mudassar
Miller, Christopher H.
Bellows, David S.
O'Toole, Ronan
[J]. TUBERCULOSIS, 2010, 90 (06) : 333 - 337
[27] Effects of CwlM on autolysis and biofilm formation in Mycobacterium tuberculosis and Mycobacterium smegmatis
Wang, Chao
Zhang, Qiaoli
Tang, Xudong
An, Yanan
Li, Shulin
Xu, Hongyue
Li, Yan
Wang, Xuefei
Luan, Wenjing
Wang, Yang
Liu, Mingyuan
Yu, Lu
[J]. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2019, 309 (01) : 73 - 83
[28] Advances in the study of innate immunity against mycobacterium tuberculosis
Nieto Ramirez, L.
Dobos, K.
[J]. CLINICA CHIMICA ACTA, 2024, 558
[29] Impact of diabetes on mechanisms of immunity against Mycobacterium tuberculosis
Rao, Shoaib
Rahim, Maryam
Iqbal, Kiran
Haroon, Fatima
Hasan, Zahra
[J]. JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2019, 69 (01) : 94 - 98
[30] Uptake of Sulfate but Not Phosphate by Mycobacterium tuberculosis Is Slower than That for Mycobacterium smegmatis
Song, Houhui
Niederweis, Michael
[J]. JOURNAL OF BACTERIOLOGY, 2012, 194 (05) : 956 - 964

← 1 2 3 4 5 →