A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

被引：0
|
作者：
Kari A Sweeney
Dee N Dao
Michael F Goldberg
Tsungda Hsu
Manjunatha M Venkataswamy
Marcela Henao-Tamayo
Diane Ordway
Rani S Sellers
Paras Jain
Bing Chen
Mei Chen
John Kim
Regy Lukose
John Chan
Ian M Orme
Steven A Porcelli
William R Jacobs
机构：
[1] Howard Hughes Medical Institute,Department of Microbiology and Immunology
[2] Albert Einstein College of Medicine,Department of Microbiology
[3] Albert Einstein College of Medicine,Department of Pathology
[4] Immunology and Pathology,Department of Medicine
[5] Colorado State University,undefined
[6] Albert Einstein College of Medicine,undefined
[7] Albert Einstein College of Medicine,undefined
来源：
Nature Medicine | 2011年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now report that an attenuated strain of Mycobacterium smegmatis expressing the esx-3 genes from Mtb induces effective CD4+ T cell dependent immunity against infection with Mtb in mice. The study offers a new avenue for the identification of protective immunogens in Mtb infection and a candidate vaccine platform warranting further study.
引用
收藏
页码：1261 / 1268
页数：7
相关论文
共 50 条
  • [1] A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis
    Sweeney, Kari A.
    Dao, Dee N.
    Goldberg, Michael F.
    Hsu, Tsungda
    Venkataswamy, Manjunatha M.
    Henao-Tamayo, Marcela
    Ordway, Diane
    Sellers, Rani S.
    Jain, Paras
    Chen, Bing
    Chen, Mei
    Kim, John
    Lukose, Regy
    Chan, John
    Orme, Ian M.
    Porcelli, Steven A.
    Jacobs, William R., Jr.
    [J]. NATURE MEDICINE, 2011, 17 (10) : 1261 - U292
  • [2] Mycobacterium smegmatis and tuberculosis
    Tyagi, JS
    Sharma, D
    [J]. TRENDS IN MICROBIOLOGY, 2002, 10 (02) : 68 - 69
  • [3] Accumulation of rifampicin by Mycobacterium aurum, Mycobacterium smegmatis and Mycobacterium tuberculosis
    Piddock, LJV
    Williams, KJ
    Ricci, V
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (02) : 159 - 165
  • [4] IS PYRAZINAMIDE BACTERICIDAL AGAINST MYCOBACTERIUM-TUBERCULOSIS
    HEIFETS, LB
    LINDHOLMLEVY, PJ
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (01): : 250 - 252
  • [5] Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis
    Nada Lelovic
    Katsuhiko Mitachi
    Junshu Yang
    Maddie R. Lemieux
    Yinduo Ji
    Michio Kurosu
    [J]. The Journal of Antibiotics, 2020, 73 : 780 - 789
  • [6] Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis
    Fridianto, Kevin T.
    Li, Ming
    Hards, Kiel
    Negatu, Dereje A.
    Cook, Gregory M.
    Dick, Thomas
    Lam, Yulin
    Go, Mei-Lin
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (21) : 15991 - 16007
  • [7] OsmC proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis protect against organic hydroperoxide stress
    Saikolappan, Sankaralingam
    Das, Kishore
    Sasindran, Smitha J.
    Jagannath, Chinnaswamy
    Dhandayuthapani, Subramanian
    [J]. TUBERCULOSIS, 2011, 91 : S119 - S127
  • [8] 8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
    Odingo, Joshua O.
    Early, Julie, V
    Smith, Jake
    Johnson, James
    Bailey, Mai A.
    Files, Megan
    Guzman, Junitta
    Ollinger, Juliane
    Korkegian, Aaron
    Kumar, Anuradha
    Ovechkina, Yulia
    Parish, Tanya
    [J]. DRUG DEVELOPMENT RESEARCH, 2019, 80 (05) : 566 - 572
  • [9] Bactericidal effect of silver nanoparticles against Mycobacterium tuberculosis
    Praba, V. Lakshmi
    Kathirvel, M.
    Vallayyachari, K.
    Surendar, K.
    Muthuraj, M.
    Jesuraj, P. Justin
    Govindarajan, S.
    Raman, K.V.
    [J]. Journal of Bionanoscience, 2013, 7 (03): : 282 - 287
  • [10] Mycobacterium bovis BCG Immunization Induces Protective Immunity against Nine Different Mycobacterium tuberculosis Strains in Mice
    Jeon, Bo Young
    Derrick, Steven C.
    Lim, JaeHyun
    Kolibab, Kristopher
    Dheenadhayalan, Veerabadran
    Yang, Amy Li
    Kreiswirth, Barry
    Morris, Sheldon L.
    [J]. INFECTION AND IMMUNITY, 2008, 76 (11) : 5173 - 5180
12345