Application of a System Model for Continuous Manufacturing of an Active Pharmaceutical Ingredient in an Industrial Environment

被引：0
|
作者：
Samir Diab
Gabriele Bano
Charalampos Christodoulou
Neil Hodnett
Antonio Benedetti
Markus Andersson
Simeone Zomer
机构：
[1] GlaxoSmithKline (GSK),
[2] GlaxoSmithKline (GSK),undefined
[3] Present: Nexeon Ltd.,undefined
来源：
Journal of Pharmaceutical Innovation | 2022年 / 17卷
关键词：
Pharmaceutical manufacturing; System modelling; Process optimization; Quality by Design (QbD); Industry 4.0;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1333 / 1346
页数：13
相关论文
共 50 条
  • [41] A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)
    Kritikos, Athanasios
    Singh, Ravendra
    Tsilomelekis, George
    Muzzio, Fernando J.
    JOURNAL OF PHARMACEUTICAL INNOVATION, 2024, 19 (02)
  • [42] Continuous-Flow TechnologyA Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
    Gutmann, Bernhard
    Cantillo, David
    Kappe, C. Oliver
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (23) : 6688 - 6728
  • [43] Characterization of an active pharmaceutical ingredient by its dissolution properties: Amoxicillin trihydrate as a model drug
    Horkovics-Kovats, S
    CHEMOTHERAPY, 2004, 50 (05) : 234 - 244
  • [44] Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient
    Yang, Yihui
    Ahmed, Bilal
    Mitchell, Christopher
    Quon, Justin L.
    Siddique, Humera
    Houson, Ian
    Florence, Alastair J.
    Papageorgiou, Charles D.
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (09) : 2119 - 2132
  • [45] Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction
    Wang, Yunchen
    Takki, Sofia
    Cheung, Ocean
    Xu, Hongyi
    Wan, Wei
    Ohrstrom, Lars
    Inge, A. Ken
    CHEMICAL COMMUNICATIONS, 2017, 53 (52) : 7018 - 7021
  • [46] Data-driven model predictive control for continuous pharmaceutical manufacturing
    Vega-Zambrano, Consuelo
    Diangelakis, Nikolaos A.
    Charitopoulos, Vassilis M.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2025, 672
  • [47] Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant
    Mesbah, Ali
    Paulson, Joel A.
    Lakerveld, Richard
    Braatz, Richard D.
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2017, 21 (06) : 844 - 854
  • [48] Optimized continuous pharmaceutical manufacturing via model-predictive control
    Rehrl, Jakob
    Kruisz, Julia
    Sacher, Stephan
    Khinast, Johannes
    Horn, Martin
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 510 (01) : 100 - 115
  • [49] Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion
    Saerens, L.
    Segher, N.
    Vervaet, C.
    Remon, J. P.
    De Beer, T.
    ANALYTICA CHIMICA ACTA, 2014, 806 : 180 - 187
  • [50] Process Analysis Tools Commonly Used in Continuous Pharmaceutical Manufacturing and Their Application Progress
    Zan, Mengqing
    Niu, Jianzhao
    Xu, Mingdi
    Liu, Qian
    Chinese Journal of Pharmaceuticals, 2022, 53 (10): : 1402 - 1407
12345