Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction

被引：90

作者：

Wang, Yunchen ^{[1
]}

Takki, Sofia ^{[1
]}

Cheung, Ocean ^{[2
]}

Xu, Hongyi ^{[1
]}

Wan, Wei ^{[1
]}

Ohrstrom, Lars ^{[3
]}

Inge, A. Ken ^{[1
]}

机构：

[1] Stockholm Univ, Dept Mat & Environm Chem, S-10691 Stockholm, Sweden

[2] Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[3] Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 52期

基金：

瑞典研究理事会;

关键词：

METAL-ORGANIC FRAMEWORK; TOMOGRAPHY; IDENTIFICATION; ANTIMONY(III); SUBSALICYLATE; SUBCITRATE; COMPLEXES; THERAPY;

D O I：

10.1039/c7cc03180g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bismuth subgallate has been used in wound and gastrointestinal therapy for over a century. The combination of continuous rotation electron diffraction and sample cooling finally revealed its structure as a coordination polymer. The structure provides insight regarding its formula, poor solubility, acid resistance and previously unreported gas sorption properties.

引用

页码：7018 / 7021

页数：4

共 12 条

[1] Structure of the active pharmaceutical ingredient bismuth subsalicylate
Erik Svensson Grape
Victoria Rooth
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Tom Willhammar
A. Ken Inge
Nature Communications, 13
[2] Structure of the active pharmaceutical ingredient bismuth subsalicylate
Grape, Erik Svensson
Rooth, Victoria
Nero, Mathias
Willhammar, Tom
Inge, A. Ken
NATURE COMMUNICATIONS, 2022, 13 (01)
[3] Solvomorphism in the active pharmaceutical ingredient bismuth subgallate: microporous 1D, 2D and 3D coordination polymers
Inge, Ken
Rooth, Victoria
Grape, Erik Svensson
Takki, Sofia
Willhammar, Tom
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2018, 74 : E367 - E367
[4] On the quality of the continuous rotation electron diffraction data for accurate atomic structure determination of inorganic compounds
Zou, Xiaodong (xzou@mmk.su.se), 1600, Wiley-Blackwell, 5 Abbey Road, Chester, CH1 2HU, United Kingdom (51):
[5] On the quality of the continuous rotation electron diffraction data for accurate atomic structure determination of inorganic compounds
Wang, Yunchen
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Xu, Hongyi
Zou, Xiaodong
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JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2018, 51 : 1094 - 1101
[6] Better structure models from continuous-rotation 3D electron diffraction data
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ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2024, 80
[7] Structure determination of a highly disordered 2D MOF by continuous rotation electron diffraction method
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Huang, Z.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2022, 78 : E709 - E709
[8] Small Pore Aluminosilicate EMM-37: Synthesis and Structure Determination Using Continuous Rotation Electron Diffraction
Kapaca, Elina
Burton, Allen
Terefenko, Eugene
Vroman, Hilda
Weston, Simon C.
Kochersperger, Meghan
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Paur, Charanjit
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INORGANIC CHEMISTRY, 2019, 58 (19) : 12854 - 12858
[9] Automated Diffraction Tomography for the Structure Elucidation of Twinned, Sub-micrometer Crystals of a Highly Porous, Catalytically Active Bismuth Metal-Organic Framework
Feyand, Mark
Mugnaioli, Enrico
Vermoortele, Frederik
Bueken, Bart
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de Vos, Dirk
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[10] Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data
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Nature Chemistry, 2023, 15 : 848 - 855

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