Chemical Modification of Plant Alkaloids. 7. T-Reaction of an Aloperine Derivative

被引：0
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作者：
K. A. Krasnov
V. G. Kartsev
E. V. Dobrokhotova
E. K. Kultyshkina
T. V. Timofeeva
V. N. Khrustalev
机构：
[1] Institute of Toxicology,Department of Chemistry & Biology
[2] Federal Medical and Biological Agency,Nesmeyanov Institute of Elementorganic Compounds
[3] ZAO Interbioscreen,undefined
[4] People’s Friendship University of Russia,undefined
[5] New Mexico Highlands University,undefined
[6] Russian Academy of Sciences,undefined
来源：
Chemistry of Natural Compounds | 2017年 / 53卷
关键词：
aloperine; -(2-carboxy-5-nitrophenyl)aloperine; 1,3-dimethylbarbituric acid; 1,3-dimethyl-5-{5-nitro-2-[3-(10-oxo-7-azatricyclo[7.3.1.02,7]trideca-11-en-12-yl)propylamino]}benzylhexahydro-2,4,6-pyrimidinetrione; hydride shift; T-reaction; -amine effect;
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学科分类号：
摘要：
N-(2-Carboxy-5-nitrophenyl)aloperine was prepared from aloperine and 2-fluoro-5-nitrobenzaldehyde and condensed with 1,3-dimethylbarbituric acid via a T-reaction with opening of the piperidine ring and formation of 1,3-dimethyl-5-{5-nitro-2-[3-(10-oxo-7-azatricyclo[7.3.1.02,7]trideca-11-en-12-yl)propylamino]} benzylhexahydro-2,4,6-pyrimidinetrione. The structure of the prepared compound was studied by an X-ray crystal structure analysis.
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页码：703 / 707
页数：4
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