Chemical modification of plant alkaloids. 4. Reaction of cotarnine with bifunctional NH- and CH-acids

被引：5
|
作者：
Krasnov, KA
Kartsev, VG
Vasilevskii, SF
机构：
[1] II Mechnikov St Petersburg State Med Acad, St Petersburg 195067, Russia
[2] ZAO Interbioskrin, Moscow 142432, Russia
[3] Russian Acad Sci, Siberian Div, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2005年 / 41卷 / 04期
关键词：
cotarnine; pyrazoles; 1,3-dicarbonyls; rearrangement;
D O I：
10.1007/s10600-005-0174-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
I-Substituted 1,2,3,4-tetrahydroisoquinoline systems were prepared by reaction of cotarnine with the NH-and CH-acids methyl- and acyl derivatives of pyrazole and 1,3-dicarbonyl reagents. Depending on the structure and reaction conditions, bifunctional pyrazole nucleophiles can give substitution products at the N atom, methyl, or acyl group; 1,3-diketones, at the terminal methyl. Rearrangements occurring during the reaction of cotarnine with bifunctional substrates were studied.
引用
收藏
页码：446 / 450
页数：5
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