A protein-RNA specificity code enables targeted activation of an endogenous human transcript

被引：0
|
作者：
Zachary T Campbell
Cary T Valley
Marvin Wickens
机构：
[1] University of Wisconsin–Madison,Department of Biochemistry
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A randomized RNA library is used to determine the specificities of RNA recognition by PUF repeats. The code is then used to design a protein that targets endogenous human cyclin B1 mRNA and activates its translation.
引用
收藏
页码：732 / 738
页数：6
相关论文
共 50 条
  • [41] A computational map of the human-SARS-CoV-2 protein-RNA interactome predicted at single-nucleotide resolution
    Horlacher, Marc
    Oleshko, Svitlana
    Hu, Yue
    Ghanbari, Mahsa
    Cantini, Giulia
    Schinke, Patrick
    Vergara, Ernesto Elorduy
    Bittner, Florian
    Mueller, Nikola S.
    Ohler, Uwe
    Moyon, Lambert
    Marsico, Annalisa
    NAR GENOMICS AND BIOINFORMATICS, 2023, 5 (01)
  • [42] Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma
    Gibb, Ewan A.
    Warren, Rene L.
    Wilson, Gavin W.
    Brown, Scott D.
    Robertson, Gordon A.
    Morin, Gregg B.
    Holt, Robert A.
    GENOME MEDICINE, 2015, 7
  • [43] Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma
    Ewan A Gibb
    René L Warren
    Gavin W Wilson
    Scott D Brown
    Gordon A Robertson
    Gregg B Morin
    Robert A Holt
    Genome Medicine, 7
  • [44] Structural basis of the RNA-binding specificity of human U1A protein
    Allain, FHT
    Howe, PWA
    Neuhaus, D
    Varani, G
    EMBO JOURNAL, 1997, 16 (18): : 5764 - 5774
  • [45] Human endogenous retroviral pol RNA and protein detected and identified in the blood of individuals with schizophrenia
    Huang, WJ
    Liu, ZC
    Wei, W
    Wang, GH
    Wu, JG
    Zhu, F
    SCHIZOPHRENIA RESEARCH, 2006, 83 (2-3) : 193 - 199
  • [46] Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging
    Wei, Yu-Ning
    Hu, Hai-Yang
    Xie, Gang-Cai
    Fu, Ning
    Ning, Zhi-Bin
    Zeng, Rong
    Khaitovich, Philipp
    GENOME BIOLOGY, 2015, 16
  • [47] Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging
    Yu-Ning Wei
    Hai-Yang Hu
    Gang-Cai Xie
    Ning Fu
    Zhi-Bin Ning
    Rong Zeng
    Philipp Khaitovich
    Genome Biology, 16
  • [48] Specificity of antibodies directed against Env protein of human endogenous retroviruses in patients with germ cell tumors
    Sauter, M
    Roemer, K
    Best, B
    Afting, M
    Schommer, S
    Seitz, G
    Hartmann, M
    MuellerLantzsch, N
    CANCER RESEARCH, 1996, 56 (19) : 4362 - 4365
  • [49] Targeted Delivery of Short Interfering RNA by Human TAR RNA-Binding Protein-Affibody Chimera
    Dar, Gulam H.
    Nathan, Erica
    Rao, Nalam M.
    Gopal, Vijaya
    MOLECULAR THERAPY, 2013, 21 : S62 - S62
  • [50] Increased resistance to recombinant human activated protein C and to activation of endogenous protein C in thrombotic antiphospholipid syndrome
    Arachchillage, D. R. Jayakody
    Efthymiou, M.
    Lawrie, A. S.
    Machin, S. J.
    Mackie, I. J.
    Cohen, H.
    BRITISH JOURNAL OF HAEMATOLOGY, 2014, 165 : 9 - 9
12345