A protein-RNA specificity code enables targeted activation of an endogenous human transcript

被引：0
|
作者：
Zachary T Campbell
Cary T Valley
Marvin Wickens
机构：
[1] University of Wisconsin–Madison,Department of Biochemistry
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
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学科分类号：
摘要：
A randomized RNA library is used to determine the specificities of RNA recognition by PUF repeats. The code is then used to design a protein that targets endogenous human cyclin B1 mRNA and activates its translation.
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页码：732 / 738
页数：6
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