A protein-RNA specificity code enables targeted activation of an endogenous human transcript

被引：0
|
作者：
Zachary T Campbell
Cary T Valley
Marvin Wickens
机构：
[1] University of Wisconsin–Madison,Department of Biochemistry
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A randomized RNA library is used to determine the specificities of RNA recognition by PUF repeats. The code is then used to design a protein that targets endogenous human cyclin B1 mRNA and activates its translation.
引用
收藏
页码：732 / 738
页数：6
相关论文
共 50 条
  • [1] A protein-RNA specificity code enables targeted activation of an endogenous human transcript
    Campbell, Zachary T.
    Valley, Cary T.
    Wickens, Marvin
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (08) : 732 - 738
  • [2] Protein-RNA recognition: Cracking the code
    Nahalka, Jozef
    JOURNAL OF THEORETICAL BIOLOGY, 2014, 343 : 9 - 15
  • [3] Breaking the protein-RNA recognition code
    Hennig, Janosch
    Gebauer, Fatima
    Sattler, Michael
    CELL CYCLE, 2014, 13 (23) : 3619 - 3620
  • [4] The role of the protein-RNA recognition code in neurodegeneration
    Nahalka, Jozef
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (11) : 2043 - 2058
  • [5] From Protein-RNA Predictions toward a Peptide-RNA Code
    Brannan, Kristopher W.
    Yeo, Gene W.
    MOLECULAR CELL, 2016, 64 (03) : 437 - 438
  • [6] Development of RNA Stiffness Parameters and Analysis on Protein-RNA Binding Specificity: Comparison with DNA
    Gromiha, M. Michael
    CURRENT BIOINFORMATICS, 2012, 7 (02) : 173 - 179
  • [7] Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites
    Feng, Huijuan
    Bao, Suying
    Rahman, Mohammad Alinoor
    Weyn-Vanhentenryck, Sebastien M.
    Khan, Aziz
    Wong, Justin
    Shah, Ankeeta
    Flynn, Elise D.
    Krainer, Adrian R.
    Zhang, Chaolin
    MOLECULAR CELL, 2019, 74 (06) : 1189 - +
  • [8] RNA activation in insects: The targeted activation of endogenous and exogenous genes
    De Hayr, Lachlan
    Asad, Sultan
    Hussain, Mazhar
    Asgari, Sassan
    INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 119
  • [9] SPECIFICITY OF PROTEIN-RNA AND PROTEIN-PROTEIN INTERACTION UPON ASSEMBLY OF TMV INVIVO AND INVITRO
    ATABEKOVA, TI
    TALIANSKY, ME
    ATABEKOV, JG
    VIROLOGY, 1975, 67 (01) : 1 - 13
  • [10] THE SPECIFICITY OF PROTEIN-RNA INTERACTIONS UPON THE ASSEMBLY OF TMV NI2519
    ATABEKOV, JG
    TALIANSKY, ME
    BIOSYSTEMS, 1980, 12 (3-4) : 249 - 256
12345