Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

被引：0

作者：

Wennuan Liu

Sari Laitinen

Sofia Khan

Mauno Vihinen

Jeanne Kowalski

Guoqiang Yu

Li Chen

Charles M Ewing

Mario A Eisenberger

Michael A Carducci

William G Nelson

Srinivasan Yegnasubramanian

Jun Luo

Yue Wang

Jianfeng Xu

William B Isaacs

Tapio Visakorpi

G Steven Bova

机构：

[1] Center for Cancer Genomics,Department of Oncology Biostatistics

[2] Wake Forest University School of Medicine,Department of Electrical and Computer Engineering

[3] Laboratory of Cancer Genetics Institute of Medical Technology,Department of Urology Genetic Medicine and Health Sciences Informatics

[4] University of Tampere and Tampere University Hospital,Department of Oncology

[5] Laboratory of Bioinformatics,Departments of Pathology

[6] Institute of Medical Technology,undefined

[7] University of Tampere and Tampere University Hospital,undefined

[8] Johns Hopkins University School of Medicine,undefined

[9] Computational Bioinformatics and Bio-imaging Laboratory,undefined

[10] Virginia Polytechnic Institute and State University,undefined

[11] Johns Hopkins University School of Medicine,undefined

[12] Genetic Medicine and Health Sciences Informatics,undefined

[13] Johns Hopkins University School of Medicine,undefined

[14] Project to Eliminate Lethal Prostate Cancer Laboratory,undefined

[15] Genetic Medicine and Health Sciences Informatics,undefined

[16] Johns Hopkins University School of Medicine,undefined

来源：

Nature Medicine | 2009年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Primary prostate cancer is genomically highly heterogeneous and is thought to derive from multiple independent clones of cancer cells. Using high-resolution genomic analyses, Bova et al. now show that, in contrast to primary tumors, metastases are monoclonal, originating from a single cancer cell. These findings call into question current views of the origins of primary prostate cancer and suggest that the genomic profile of prostate cancer metastases should inform therapeutic decisions.

引用

页码：559 / 565

页数：6

共 50 条

[41] Integrated clinics whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer
Bova, G. Steven
Kallio, Heini M. L.
Annala, Matti
Kivinummi, Kati
Hognas, Gunilla
Hayrynen, Sergei
Rantapero, Tommi
Kivinen, Virpi
Isaacs, William B.
Tolonen, Teemu
Nykter, Matti
Visakorpi, Tapio
COLD SPRING HARBOR MOLECULAR CASE STUDIES, 2016, 2 (03):
[42] Copy number aberrations in prostate cancer cell lines by single nucleotide polymorphism array analysis
Ricke, W. A.
Lee, Y-F.
Messing, E. M.
Reeder, J. E.
BJU INTERNATIONAL, 2007, 100 : 36 - 37
[43] Copy Number Analysis in Cancer Diagnostic Testing
Spence, Tara
Dubuc, Adrian M.
CLINICS IN LABORATORY MEDICINE, 2022, 42 (03) : 451 - 468
[44] Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis
Conteduca, Vincenza
Ku, Sheng-Yu
Fernandez, Luisa
Dago-Rodriquez, Angel
Lee, Jerry
Jendrisak, Adam
Slade, Megan
Gilbertson, Cole
Manohar, Jyothi
Sigouros, Michael
Wang, Yipeng
Dittamore, Ryan
Wenstrup, Rick
Mosquera, Juan Miguel
Schonhoft, Joseph D.
Beltran, Himisha
NPJ PRECISION ONCOLOGY, 2021, 5 (01)
[45] ANALYSIS OF COPY NUMBER ABERRATION IN BREAST CANCER
Taira, F.
Takahashi, Y.
Saito, M.
Kanatani, A.
Akashi, K.
Ito, T.
Murakami, Y.
ANNALS OF ONCOLOGY, 2013, 24
[46] Clustering-Based Method for Developing a Genomic Copy Number Alteration Signature for Predicting the Metastatic Potential of Prostate Cancer
Pearlman, Alexander
Campbell, Christopher
Brooks, Eric
Genshaft, Alex
Shajahan, Shahin
Ittman, Michael
Bova, G. Steven
Melamed, Jonathan
Holcomb, Ilona
Schneider, Robert J.
Ostrer, Harry
JOURNAL OF PROBABILITY AND STATISTICS, 2012, 2012
[47] Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer
Salvi, Samanta
Casadio, Valentina
Conteduca, Vincenza
Lolli, Cristian
Gurioli, Giorgia
Martignano, Filippo
Schepisi, Giuseppe
Testoni, Sara
Scarpi, Emanuela
Amadori, Dino
Calistri, Daniele
Attard, Gerhardt
De Giorgi, Ugo
ONCOTARGET, 2016, 7 (25) : 37839 - 37845
[48] Copy Number Alterations that Predict Metastatic Capability of Human Breast Cancer
Zhang, Yi
Martens, John W. M.
Yu, Jack X.
Jiang, John
Sieuwerts, Anieta M.
Smid, Marcel
Klijn, Jan G. M.
Wang, Yixin
Foekens, John A.
CANCER RESEARCH, 2009, 69 (09) : 3795 - 3801
[49] Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry
Albawardi, Alia
Livingstone, Julie
Almarzooqi, Saeeda
Palanisamy, Nallasivam
Houlahan, Kathleen E.
Awwad, Aktham Adnan Ahmad
Abdelsalam, Ramy A.
Boutros, Paul C.
Bismar, Tarek A.
CANCERS, 2021, 13 (10)
[50] A prospective study of mitochondrial DNA copy number and the risk of prostate cancer
Amy Moore
Qing Lan
Jonathan N. Hofmann
Chin-San Liu
Wen-Ling Cheng
Ta-Tsung Lin
Sonja I. Berndt
Cancer Causes & Control, 2017, 28 : 529 - 538

← 1 2 3 4 5 →