Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

被引：0

作者：

Wennuan Liu

Sari Laitinen

Sofia Khan

Mauno Vihinen

Jeanne Kowalski

Guoqiang Yu

Li Chen

Charles M Ewing

Mario A Eisenberger

Michael A Carducci

William G Nelson

Srinivasan Yegnasubramanian

Jun Luo

Yue Wang

Jianfeng Xu

William B Isaacs

Tapio Visakorpi

G Steven Bova

机构：

[1] Center for Cancer Genomics,Department of Oncology Biostatistics

[2] Wake Forest University School of Medicine,Department of Electrical and Computer Engineering

[3] Laboratory of Cancer Genetics Institute of Medical Technology,Department of Urology Genetic Medicine and Health Sciences Informatics

[4] University of Tampere and Tampere University Hospital,Department of Oncology

[5] Laboratory of Bioinformatics,Departments of Pathology

[6] Institute of Medical Technology,undefined

[7] University of Tampere and Tampere University Hospital,undefined

[8] Johns Hopkins University School of Medicine,undefined

[9] Computational Bioinformatics and Bio-imaging Laboratory,undefined

[10] Virginia Polytechnic Institute and State University,undefined

[11] Johns Hopkins University School of Medicine,undefined

[12] Genetic Medicine and Health Sciences Informatics,undefined

[13] Johns Hopkins University School of Medicine,undefined

[14] Project to Eliminate Lethal Prostate Cancer Laboratory,undefined

[15] Genetic Medicine and Health Sciences Informatics,undefined

[16] Johns Hopkins University School of Medicine,undefined

来源：

Nature Medicine | 2009年 / 15卷

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学科分类号：

摘要：

Primary prostate cancer is genomically highly heterogeneous and is thought to derive from multiple independent clones of cancer cells. Using high-resolution genomic analyses, Bova et al. now show that, in contrast to primary tumors, metastases are monoclonal, originating from a single cancer cell. These findings call into question current views of the origins of primary prostate cancer and suggest that the genomic profile of prostate cancer metastases should inform therapeutic decisions.

引用

页码：559 / 565

页数：6

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