Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

被引：0

作者：

Wennuan Liu

Sari Laitinen

Sofia Khan

Mauno Vihinen

Jeanne Kowalski

Guoqiang Yu

Li Chen

Charles M Ewing

Mario A Eisenberger

Michael A Carducci

William G Nelson

Srinivasan Yegnasubramanian

Jun Luo

Yue Wang

Jianfeng Xu

William B Isaacs

Tapio Visakorpi

G Steven Bova

机构：

[1] Center for Cancer Genomics,Department of Oncology Biostatistics

[2] Wake Forest University School of Medicine,Department of Electrical and Computer Engineering

[3] Laboratory of Cancer Genetics Institute of Medical Technology,Department of Urology Genetic Medicine and Health Sciences Informatics

[4] University of Tampere and Tampere University Hospital,Department of Oncology

[5] Laboratory of Bioinformatics,Departments of Pathology

[6] Institute of Medical Technology,undefined

[7] University of Tampere and Tampere University Hospital,undefined

[8] Johns Hopkins University School of Medicine,undefined

[9] Computational Bioinformatics and Bio-imaging Laboratory,undefined

[10] Virginia Polytechnic Institute and State University,undefined

[11] Johns Hopkins University School of Medicine,undefined

[12] Genetic Medicine and Health Sciences Informatics,undefined

[13] Johns Hopkins University School of Medicine,undefined

[14] Project to Eliminate Lethal Prostate Cancer Laboratory,undefined

[15] Genetic Medicine and Health Sciences Informatics,undefined

[16] Johns Hopkins University School of Medicine,undefined

来源：

Nature Medicine | 2009年 / 15卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Primary prostate cancer is genomically highly heterogeneous and is thought to derive from multiple independent clones of cancer cells. Using high-resolution genomic analyses, Bova et al. now show that, in contrast to primary tumors, metastases are monoclonal, originating from a single cancer cell. These findings call into question current views of the origins of primary prostate cancer and suggest that the genomic profile of prostate cancer metastases should inform therapeutic decisions.

引用

页码：559 / 565

页数：6

共 50 条

[1] Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Liu, Wennuan
Laitinen, Sari
Khan, Sofia
Vihinen, Mauno
Kowalski, Jeanne
Yu, Guoqiang
Chen, Li
Ewing, Charles M.
Eisenberger, Mario A.
Carducci, Michael A.
Nelson, William G.
Yegnasubramanian, Srinivasan
Luo, Jun
Wang, Yue
Xu, Jianfeng
Isaacs, William B.
Visakorpi, Tapio
Bova, Steven
NATURE MEDICINE, 2009, 15 (05) : 559 - 565
[2] Re: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Marks, Leonard S.
Huang, Jiaoti
EUROPEAN UROLOGY, 2010, 57 (04) : 727 - 728
[3] Erratum: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Wennuan Liu
Sari Laitinen
Sofia Khan
Mauno Vihinen
Jeanne Kowalski
Guoqiang Yu
Li Chen
Charles M Ewing
Mario A Eisenberger
Michael A Carducci
William G Nelson
Srinivasan Yegnasubramanian
Jun Luo
Yue Wang
Jianfeng Xu
William B Isaacs
Tapio Visakorpi
G Steven Bova
Nature Medicine, 2009, 15 : 819 - 819
[4] Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer Editorial Comment
Atala, Anthony
JOURNAL OF UROLOGY, 2010, 183 (01): : 394 - 394
[5] Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer (vol 15, pg 559, 2009)
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[6] Copy number alterations are associated with metastatic-lethal progression in prostate cancer
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