Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia

被引：0
|
作者：
Rene Przkora
P. Falkai
Andreas von Deimling
Otmar D. Wiestler
Margot Albus
Marcella Rietschel
Wolfgang Maier
Thomas A. Bayer
机构：
[1] Department of Neuropathology,
[2] University of Bonn Medical Center,undefined
[3] Sigmund-Freud-Strasse 25,undefined
[4] D-53105 Bonn,undefined
[5] Germany,undefined
[6] Department of Psychiatry,undefined
[7] University of Bonn Medical Center,undefined
[8] Sigmund-Freud-Strasse 25,undefined
[9] D-53105 Bonn,undefined
[10] Germany,undefined
[11] State Mental Hospital Haar,undefined
[12] Vockestrasse 72,undefined
[13] D-85540 Haar,undefined
[14] Germany,undefined
来源：
European Archives of Psychiatry and Clinical Neuroscience | 1998年 / 248卷
关键词：
Key words Schizophrenia; SSCP; TSC2;
D O I：
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中图分类号：
学科分类号：
摘要：
The tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of malformations in various organs including the brain. A polymorphism in the TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell migration pattern. Since these pathomorphological changes are compatible with disturbed neuronal migration in schizophrenic brains, we investigated this polymorphism in 130 families with a schizophrenic index patient. A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia.
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页码：314 / 315
页数：1
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