Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia

被引：0
|
作者：
Rene Przkora
P. Falkai
Andreas von Deimling
Otmar D. Wiestler
Margot Albus
Marcella Rietschel
Wolfgang Maier
Thomas A. Bayer
机构：
[1] Department of Neuropathology,
[2] University of Bonn Medical Center,undefined
[3] Sigmund-Freud-Strasse 25,undefined
[4] D-53105 Bonn,undefined
[5] Germany,undefined
[6] Department of Psychiatry,undefined
[7] University of Bonn Medical Center,undefined
[8] Sigmund-Freud-Strasse 25,undefined
[9] D-53105 Bonn,undefined
[10] Germany,undefined
[11] State Mental Hospital Haar,undefined
[12] Vockestrasse 72,undefined
[13] D-85540 Haar,undefined
[14] Germany,undefined
来源：
European Archives of Psychiatry and Clinical Neuroscience | 1998年 / 248卷
关键词：
Key words Schizophrenia; SSCP; TSC2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of malformations in various organs including the brain. A polymorphism in the TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell migration pattern. Since these pathomorphological changes are compatible with disturbed neuronal migration in schizophrenic brains, we investigated this polymorphism in 130 families with a schizophrenic index patient. A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia.
引用
收藏
页码：314 / 315
页数：1
相关论文
共 50 条
  • [31] The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses
    Rosner, M
    Freilinger, A
    Lubec, G
    Hengstschläger, M
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2005, 27 (05) : 1411 - 1424
  • [32] Mutational analysis of TSC1 and TSC2 in Danish patients with tuberous sclerosis complex
    Thomas Rosengren
    Santoesha Nanhoe
    Luis Gustavo Dufner de Almeida
    Bitten Schönewolf-Greulich
    Lasse Jonsgaard Larsen
    Caroline Amalie Brunbjerg Hey
    Morten Dunø
    Jakob Ek
    Lotte Risom
    Mark Nellist
    Lisbeth Birk Møller
    Scientific Reports, 10
  • [33] Analysis of TSC1 and TSC2 genes and evaluation of phenotypic correlations with tuberous sclerosis
    Eser, Metin
    Hekimoglu, Gulam
    Kutlubay, Busra
    Sager, Safiye Gunes
    Turkyilmaz, Ayberk
    MOLECULAR GENETICS AND GENOMICS, 2025, 300 (01)
  • [34] Novel TSC1 and TSC2 gene mutations in Chinese patients with tuberous sclerosis complex
    Yu, Tingting
    He, Yingzhong
    Li, Niu
    Zhou, Yunqing
    Wang, Zhiping
    Fu, Qihua
    Wang, Jiwen
    Wang, Jian
    CLINICAL NEUROLOGY AND NEUROSURGERY, 2017, 154 : 104 - 108
  • [35] Mutational analysis of TSC1 and TSC2 in Korean patients with tuberous sclerosis complex
    Choi, Ji-Eun
    Chae, Jong-Hee
    Hwang, Yong-Seung
    Kim, Ki-Joong
    BRAIN & DEVELOPMENT, 2006, 28 (07): : 440 - 446
  • [36] Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients
    Au, KS
    Rodriguez, JA
    Finch, JL
    Volcik, KA
    Roach, ES
    Delgado, MR
    Rodriguez, E
    Northrup, H
    AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (02) : 286 - 294
  • [37] Analysis of TSC2 stop codon variants found in tuberous sclerosis patients
    Miriam A Goedbloed
    Mark Nellist
    Brenda Verhaaf
    Arnold JJ Reuser
    Dick Lindhout
    Lone Sunde
    Senno Verhoef
    Dicky JJ Halley
    Ans MW van den Ouweland
    European Journal of Human Genetics, 2001, 9 : 823 - 828
  • [38] Analysis of TSC2 stop codon variants found in tuberous sclerosis patients
    Goedbloed, MA
    Nellist, M
    Verhaaf, B
    Reuser, AJJ
    Lindhout, D
    Sunde, L
    Verhoef, S
    Halley, DJJ
    van den Ouweland, AMW
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (11) : 823 - 828
  • [39] A multi-step sequential approach for tuberous sclerosis gene 2 (TSC2) mutation analysis.
    Longa, L
    Polidoro, S
    Padovan, S
    Meo, T
    Carbonara, C
    Brusco, A
    Grosso, E
    Migone, N
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A411 - A411
  • [40] Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
    Carsillo, T
    Astrinidis, A
    Henske, EP
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) : 6085 - 6090
12345