The Effect of Hepatocarcinogen o-Aminoazotoluene on Induction of Mouse Liver Tyrosine Aminotransferase by Glucocorticoids

被引：0
|
作者：
K. Yu. Kropachev
V. I. Kaledin
O. A. Timofeeva
S. I. Il'nitskaya
E. D. Vasil'eva
S. Yu. Plisov
N. A. Rychkova
M. L. Filipenko
T. I. Merkulova
机构：
[1] Institute of Cytology and Genetics,Siberian Division, Russian Academy of Sciences
[2] Novosibirsk Institute of Bioorganic Chemistry,Siberian Division, Russian Academy of Sciences
来源：
Molecular Biology | 2001年 / 35卷
关键词：
tyrosine aminotransferase; -aminoazotoluene; glucocorticoid induction; transcription factors; HNF3; hepatocarcinogenesis;
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摘要：
o-Aminoazotoluene (OAT) suppressed more than twofold the glucocorticoid induction of tyrosine aminotransferase in the liver of SWR mice, which are sensitive to the hepatocarcinogenic effect of OAT, but not in resistant AKR mice. The hormone- and DNA-binding activities of the glucocorticoid receptor were not affected in either strain. The OAT-dependent suppression proved to be associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts. The content of the HNF3 mRNA did not change, suggesting a posttranscriptional effect of OAT.
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页码：392 / 398
页数：6
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