The Effect of Hepatocarcinogen o-Aminoazotoluene on Induction of Mouse Liver Tyrosine Aminotransferase by Glucocorticoids

被引：0
|
作者：
K. Yu. Kropachev
V. I. Kaledin
O. A. Timofeeva
S. I. Il'nitskaya
E. D. Vasil'eva
S. Yu. Plisov
N. A. Rychkova
M. L. Filipenko
T. I. Merkulova
机构：
[1] Institute of Cytology and Genetics,Siberian Division, Russian Academy of Sciences
[2] Novosibirsk Institute of Bioorganic Chemistry,Siberian Division, Russian Academy of Sciences
来源：
Molecular Biology | 2001年 / 35卷
关键词：
tyrosine aminotransferase; -aminoazotoluene; glucocorticoid induction; transcription factors; HNF3; hepatocarcinogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
o-Aminoazotoluene (OAT) suppressed more than twofold the glucocorticoid induction of tyrosine aminotransferase in the liver of SWR mice, which are sensitive to the hepatocarcinogenic effect of OAT, but not in resistant AKR mice. The hormone- and DNA-binding activities of the glucocorticoid receptor were not affected in either strain. The OAT-dependent suppression proved to be associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts. The content of the HNF3 mRNA did not change, suggesting a posttranscriptional effect of OAT.
引用
收藏
页码：392 / 398
页数：6
相关论文
共 50 条
  • [21] BINDING OF O-AMINOAZOTOLUENE TO DEOXYRIBONUCLEIC ACID RIBONUCLEIC ACID AND PROTEIN IN C57 MOUSE
    LAWSON, TA
    BIOCHEMICAL JOURNAL, 1968, 109 (05) : 917 - &
  • [22] Activity and inducibility of cytochrome P-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene
    Gulyaeva, LF
    Zakharova, LY
    Lyakhovich, VV
    Morozkova, TS
    Kaledin, VI
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1998, 126 (08) : 820 - 822
  • [23] INDUCTION OF TYROSINE AMINOTRANSFERASE IN ISOLATED LIVER CELLS
    HUANG, YL
    EBNER, KE
    BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 191 (01) : 161 - &
  • [24] DYNAMIC ASYMMETRIES IN LIVER TYROSINE AMINOTRANSFERASE INDUCTION
    STEFAN, M
    GHEORGHE, N
    ENZYME, 1976, 21 (05) : 459 - 463
  • [25] Activity and inducibility of cytochrome P-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene
    L. F. Gulyaeva
    L. Yu. Zakharova
    V. V. Lyakhorich
    T. S. Morozkova
    V. I. Kaledin
    Bulletin of Experimental Biology and Medicine, 1998, 126 : 820 - 822
  • [26] Glutathione S-transferase activity in the liver of mice with different sensitivity to hepatocarcinogenic effects of o-aminoazotoluene
    Zakharova, LY
    Gulyaeva, LF
    Narkhova, OV
    Kaledin, VI
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2000, 129 (02) : 149 - 150
  • [27] COVALENT BINDING OF [3H]O-AMINOAZOTOLUENE TO C57 MOUSE LIVER DEOXYRIBONUCLEIC ACID RIBONUCLEIC ACID AND PROTEIN
    LAWSON, TA
    BIOCHEMICAL JOURNAL, 1968, 107 (04) : P14 - &
  • [28] Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood
    Baginskaya, N. V.
    Il'nitskaya, S. I.
    Nikitenko, E. V.
    Kaledin, V. I.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (06) : 821 - 824
  • [29] Regulation of tyrosine aminotransferase gene expression by glucocorticoids in quiescent and regenerating liver
    Baki, L
    Alexis, MN
    BIOCHEMICAL JOURNAL, 1996, 320 : 745 - 753
  • [30] Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis
    Timofeeva, Olga A.
    Eremeev, Artem V.
    Goloshchapov, Andrey
    Kalashnikova, Eugenia
    Ilnitskaya, Svetlana
    Setkov, Nikolai A.
    Kobzev, Victor
    Buzard, Gregory S.
    Filipenko, Maxim L.
    Kaledin, Vasily .
    Merkulova, Tatyana I.
    TOXICOLOGY, 2008, 254 (1-2) : 91 - 96
12345