Depolarization- and α-Latrotoxin-Induced [3H]GABA Release from the Rat Brain Synaptosomes: Effect of Phenylarsine Oxide

被引：0
|
作者：
M. V. Linetska
L. G. Storchak
N. G. Himmelreich
机构：
[1] National Academy of Sciences of Ukraine,Palladin Institute of Biochemistry
来源：
Neurophysiology | 2002年 / 34卷
关键词：
synaptosomes; 4-aminopyridine; α-latrotoxin; phenylarsine oxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phosphatidylinositol 4,5-biphosphate has been implicated in a variety of cellular processes, including neurotransmitter release. Here we present evidence for the strong influence of an inhibitor of phosphatidylinositol 4-kinase, phenylarsine oxide, on depolarization- and α-latrotoxin-evoked exocytotic release of [3H]GABA from the rat brain synaptosomes. Our data also show that subnanomolar concentrations of the toxin stimulate the process of exocytosis per se, while nanomolar toxin concentrations in addition cause neurotransmitter outflow from the cytosolic pool.
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页码：171 / 172
页数：1
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