Depolarization- and α-Latrotoxin-Induced [3H]GABA Release from the Rat Brain Synaptosomes: Effect of Phenylarsine Oxide

被引：0
|
作者：
M. V. Linetska
L. G. Storchak
N. G. Himmelreich
机构：
[1] National Academy of Sciences of Ukraine,Palladin Institute of Biochemistry
来源：
Neurophysiology | 2002年 / 34卷
关键词：
synaptosomes; 4-aminopyridine; α-latrotoxin; phenylarsine oxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phosphatidylinositol 4,5-biphosphate has been implicated in a variety of cellular processes, including neurotransmitter release. Here we present evidence for the strong influence of an inhibitor of phosphatidylinositol 4-kinase, phenylarsine oxide, on depolarization- and α-latrotoxin-evoked exocytotic release of [3H]GABA from the rat brain synaptosomes. Our data also show that subnanomolar concentrations of the toxin stimulate the process of exocytosis per se, while nanomolar toxin concentrations in addition cause neurotransmitter outflow from the cytosolic pool.
引用
收藏
页码：171 / 172
页数：1
相关论文
共 50 条
  • [21] TETANUS TOXIN INHIBITS DEPOLARIZATION-INDUCED [H-3] SEROTONIN RELEASE FROM RAT-BRAIN CORTEX SYNAPTOSOMES
    GOBBI, M
    FACCHIANO, F
    FRITTOLI, E
    LUINI, A
    MENNINI, T
    NEUROSCIENCE LETTERS, 1993, 151 (02) : 205 - 208
  • [22] Putrescine modulation of depolarization-induced [H-3]serotonin release from fish brain synaptosomes
    Khan, NA
    Moulinoux, P
    Deschaux, P
    NEUROSCIENCE LETTERS, 1996, 212 (01) : 45 - 48
  • [23] Dopamine D4 receptors inhibit depolarization-induced [3H]GABA release in the rat subthalamic nucleus
    Floran, B
    Floran, L
    Erlij, D
    Aceves, J
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 498 (1-3) : 97 - 102
  • [24] THE EFFECT OF ALPHA-LATROTOXIN ON THE PROCESSES OF GLUTAMATE UPTAKE AND RELEASE IN RAT-BRAIN SYNAPTOSOMES
    ZHARIKOV, SI
    ZHARIKOVA, AD
    POPOV, VI
    PASHKOV, VN
    GRISHIN, EV
    BIOLOGICHESKIE MEMBRANY, 1990, 7 (10): : 1013 - 1021
  • [25] Effect of Nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes
    A. Cupello
    P. Mainardi
    M. Robello
    S. Thellung
    Neurochemical Research, 1997, 22 : 1517 - 1521
  • [26] Effect of nitric oxide donors on GABA uptake by rat brain synaptosomes
    Cupello, A
    Mainardi, P
    Robello, M
    Thellung, S
    NEUROCHEMICAL RESEARCH, 1997, 22 (12) : 1517 - 1521
  • [27] The effect of calcium channels blockers in the K+-evoked release of [3H]adenine nucleotides from rat brain cortical synaptosomes
    Mesquita, F
    Prado, MAM
    Gomez, RS
    Romano-Silva, MA
    Gomez, MV
    NEUROSCIENCE LETTERS, 1998, 258 (01) : 57 - 59
  • [28] Histamine H3 Receptor Activation Counteracts Adenosine A2A Receptor-Mediated Enhancement of Depolarization-Evoked [3H]-GABA Release from Rat Globus Pallidus Synaptosomes
    Morales-Figueroa, Guadalupe-Elide
    Marquez-Gomez, Ricardo
    Gonzalez-Pantoja, Raul
    Escamilla-Sanchez, Juan
    Arias-Montano, Jose-Antonio
    ACS CHEMICAL NEUROSCIENCE, 2014, 5 (08): : 637 - 645
  • [29] Effect of novel α-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes
    Azam, L
    McIntosh, JM
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 312 (01): : 231 - 237
  • [30] Effects of desipramine and bupropion on noradrenaline-induced [3H]-dopamine ([3H]-DA) release in rat striatal and hypothalamic synaptosomes
    Hospital, S
    Badia, A
    Clos, MV
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R99 - R99
12345