Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus

被引：0
|
作者：
O. I. Koifman
V. E. Maizlish
M. O. Koifman
N. Sh. Lebedeva
E. S. Yurina
Yu. A. Gubarev
E. L. Gur’ev
机构：
[1] Russian Academy of Sciences,G. A. Krestov Institute of Solution Chemistry
[2] Ivanovo State University of Chemistry and Technology,undefined
[3] Lobachesky State University of Nizhny Novgorod,undefined
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
phthalocyanine; protein; virus SARS-CoV-2; complex formation; photooxidation;
D O I：
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学科分类号：
摘要：
Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain. The photoirradiation of the complex of ORF3a protein of SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine leads to the photooxidation of amino acid residues of the protein.
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页码：233 / 238
页数：5
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