Brain proton magnetic spectroscopy in long-term treatment of Wilson’s disease patients

被引：0

作者：

Beata Tarnacka

Wojciech Szeszkowski

Marek Gołębiowski

Anna Członkowska

机构：

[1] Institute of Psychiatry and Neurology,2nd Neurological Department

[2] Warsaw Medical University,II Department of Clinical Radiology

[3] Warsaw Medical University,I Department of Clinical Radiology

[4] Medical Academy,Department of Clinical and Experimental Pharmacology

来源：

Metabolic Brain Disease | 2010年 / 25卷

关键词：

Wilson disease; Magnetic resonance spectroscopy; Treatment;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson’s disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated 4 hWD patients, with no improvement and 8 with marked improvement; and 8 nWD patients with marked improvement and 7 with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.

引用

页码：375 / 379

页数：4

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