Brain proton magnetic spectroscopy in long-term treatment of Wilson’s disease patients

被引：0
|
作者：
Beata Tarnacka
Wojciech Szeszkowski
Marek Gołębiowski
Anna Członkowska
机构：
[1] Institute of Psychiatry and Neurology,2nd Neurological Department
[2] Warsaw Medical University,II Department of Clinical Radiology
[3] Warsaw Medical University,I Department of Clinical Radiology
[4] Medical Academy,Department of Clinical and Experimental Pharmacology
来源：
Metabolic Brain Disease | 2010年 / 25卷
关键词：
Wilson disease; Magnetic resonance spectroscopy; Treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson’s disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated 4 hWD patients, with no improvement and 8 with marked improvement; and 8 nWD patients with marked improvement and 7 with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.
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页码：375 / 379
页数：4
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