Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells

被引：0
|
作者：
Matthew J Frontini
Zengxuan Nong
Robert Gros
Maria Drangova
Caroline O'Neil
Mona N Rahman
Oula Akawi
Hao Yin
Christopher G Ellis
J Geoffrey Pickering
机构：
[1] Robarts Research Institute,Department of Medicine (Cardiology)
[2] Schulich School of Medicine and Dentistry,Department of Biochemistry
[3] University of Western Ontario,Department of Medical Biophysics
[4] London,Department of Physiology and Pharmacology
[5] Canada and London Health Sciences Centre,undefined
[6] Schulich School of Medicine and Dentistry,undefined
[7] University of Western Ontario,undefined
[8] Schulich School of Medicine and Dentistry,undefined
[9] University of Western Ontario,undefined
[10] Schulich School of Medicine and Dentistry,undefined
[11] University of Western Ontario,undefined
[12] Schulich School of Medicine and Dentistry,undefined
[13] University of Western Ontario,undefined
来源：
Nature Biotechnology | 2011年 / 29卷
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摘要：
Frontini et al. propose to improve therapeutic angiogenesis by targeting perivascular smooth muscle cells rather than endothelial cells. They show that FGF9 causes smooth muscle cells to wrap around nascent endothelial tubes, generating blood vessels that are longer lasting and vasoreactive.
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页码：421 / 427
页数：6
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