Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

被引：0

作者：

Richard Cowper-Sal·lari

Xiaoyang Zhang

Jason B Wright

Swneke D Bailey

Michael D Cole

Jerome Eeckhoute

Jason H Moore

Mathieu Lupien

机构：

[1] Norris Cotton Cancer Center,Department of Genetics

[2] Dartmouth Medical School,Department of Medical Biophysics

[3] Institute for Quantitative Biomedical Sciences,undefined

[4] Norris Cotton Cancer Center,undefined

[5] Dartmouth Medical School,undefined

[6] Ontario Cancer Institute,undefined

[7] Princess Margaret Hospital–University Health Network,undefined

[8] University of Toronto,undefined

[9] Institut National de la Santé et de la Recherche Médicale (INSERM),undefined

[10] Unité Mixte de Recherche (UMR) 1011,undefined

[11] Université de Lille Nord de France,undefined

[12] Institut Pasteur de Lille,undefined

来源：

Nature Genetics | 2012年 / 44卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Mathieu Lupien, Jason Moore and colleagues show that breast cancer risk–associated SNPs commonly disrupt the binding of FOXA1 to chromatin, thereby directly affecting gene expression.

引用

页码：1191 / 1198

页数：7

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