FOXA1 and breast cancer risk

被引：18
|
作者：
Meyer, Kerstin B. [1 ,2 ]
Carroll, Jason S. [1 ,2 ]
机构：
[1] Canc Res UK, Cambridge, England
[2] Univ Cambridge, Dept Oncol, Cambridge, England
来源：
NATURE GENETICS | 2012年 / 44卷 / 11期
关键词：
GENOME-WIDE ASSOCIATION; ESTROGEN; TRANSCRIPTION; CHROMATIN; ALPHA;
D O I：
10.1038/ng.2449
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Many SNPs associated with human disease are located in non-coding regions of the genome. A new study shows that SNPs associated with breast cancer risk are located in enhancer regions and alter binding affinity for the pioneer factor FOXA1.
引用
收藏
页码：1176 / 1177
页数：2
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