Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk

被引：0
|
作者：
Jordi To-Figueras
Manel Gené
Jesús Gómez-catalán
Esther Piqué
Natividad Borrego
Josep Lluís Carrasco
Josep Ramón
Jacint Corbella
机构：
[1] University of Barcelona,Toxicology Unit, IDIBAPS [Institut d'Investigacions Biomèdiques August Pi i Sunye
[2] University of Barcelona,Department of Public Health
来源：
Cancer Causes & Control | 1999年 / 10卷
关键词：
GSTM1; GSTP1; GSTT1; lung cancer; polymorphisms; susceptibility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objectives: The human GSTTP1 gene is polymorphic with an A → G transition in exon 5 causing a replacement 105 Ile→Val in the GSTP1 protein. The two isoforms, encoded by the alleles GSTP1*A and GSTP1*B, respectively, show different catalytic efficiencies towards some carcinogenic epoxides. In this study we have addressed the possible role of the Ile105Val GSTP1 polymorphism in lung cancer susceptibility.
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页码：65 / 70
页数：5
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