Alteration of bcl-2 and bax expression in embolized meningiomas.

被引：7
|
作者：
Nakasu S. [1 ]
Nakajima M. [1 ]
Nakazawa T. [1 ]
Nakasu Y. [1 ]
Handa J. [1 ]
机构：
[1] Department of Neurosurgery, Shiga University of Medical Science
来源：
Brain Tumor Pathology | 1998年 / 15卷 / 1期
关键词：
Apoptosis; Embolization; Meningioma;
D O I：
10.1007/BF02482095
中图分类号：
学科分类号：
摘要：
We examined the expression of the p53 and bcl-2 family in embolized meningiomas and investigated the interaction between them. p53 and its downstream effector p21 accumulated mainly in perinecrotic areas, where apoptosis was also observed. bcl-2 was often expressed in the areas distant from necrosis, whereas Bax was immunostained more intensely in the perinecrotic areas. Double staining for both p53 and Bcl-2 showed a reciprocal pattern. This appeared to be due to the down-regulation of Bcl-2 by p53. However, regulation of Bax by p53 was not distinct. The expression of p21 was not apparent 13 days after embolization, and apoptosis was observed until 6 days after embolization. The effect of embolization was most likely temporary, although growth arrest has been reported to persist for a long time in a limited number of embolized cases.
引用
收藏
页码：13 / 17
页数：4
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