Progesterone Receptor, Bcl-2 and Bax Expression in Meningiomas

被引：0
|
作者：
F.M. Verheijen
G.H. Donker
C. Sales Viera
M. Sprong
H.M. Jacobs
G. Blaauw
J.H.H. Thijssen
M.A. Blankenstein
机构：
[1] University Medical Center Utrecht,Department of Endocrinology
[2] De Wever Hospital,Department of Neurosurgery
来源：
Journal of Neuro-Oncology | 2002年 / 56卷
关键词：
Bax; bcl-2; breast cancer; estrogen receptor; immunoblotting; meningioma; progesterone receptor;
D O I：
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中图分类号：
学科分类号：
摘要：
Meningiomas are generally benign central nervous system neoplasms, which frequently express progesterone receptor (PR) and only rarely express the estrogen receptor (ER). For breast cancer, a relation between steroid hormone receptors and proteins involved in the apoptotic process has been described. For meningiomas, the exact relation between PR and these proteins is not known. In this study, ER, PR, bcl-2 and bcl-2-associated × protein (Bax) expression levels were determined in meningioma cytosols. As a reference for our experimental conditions, we also determined these proteins in breast cancer cytosols.
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页码：35 / 41
页数：6
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