Expression of bcl-2 and bax in glomerular disease

被引:17
|
作者
Yoshimura, A [1 ]
Uda, S [1 ]
Inui, K [1 ]
Nemoto, T [1 ]
Sugenoya, Y [1 ]
Sharif, S [1 ]
Yokota, N [1 ]
Watanabe, S [1 ]
Ideura, T [1 ]
机构
[1] Showa Univ, Fujigaoka Hosp, Dept Med, Div Nephrol,Aoba Ku, Yokohama, Kanagawa 227, Japan
关键词
D O I
10.1093/ndt/14.suppl_1.55
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Bcl-2 may account in part for the maintenance of hypercellularity in human glomerular diseases through preventing cell death and by counteracting bax which may be expressed to regulate excessive proliferation. This process is associated with the effect of PDGF B-chain expression. Bax expression may be important in the cell loss leading to glomerulosclerosis and TGF-beta 1 participates in this process by increasing bax expression. Thus, the balance of bcl-2/bax expression may be critical in the course of human glomerular diseases.
引用
收藏
页码:55 / 57
页数:3
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