Strategies Used in the Detection of Acute/Early HIV Infections. The NIMH Multisite Acute HIV Infection Study: I

被引:0
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作者
Peter R. Kerndt
Robert Dubrow
Getahun Aynalem
Kenneth H. Mayer
Curt Beckwith
Robert H. Remien
Hong-Ha M. Truong
Apurva Uniyal
Michael Chien
Ronald A. Brooks
Ofilio R. Vigil
Wayne T. Steward
Michael Merson
Mary Jane Rotheram-Borus
Stephen F. Morin
机构
[1] Los Angeles County Department of Public Health,Center for Interdisciplinary Research on AIDS
[2] Sexually Trasmitted Disease Program,HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute
[3] Yale University,Center for AIDS Prevention Studies
[4] Brown University,Center for HIV Identification, Prevention and Treatment Services
[5] Columbia University,HIV Neurobehavioral Research Center
[6] University of California,undefined
[7] University of California,undefined
[8] University of California,undefined
[9] Duke University,undefined
来源
AIDS and Behavior | 2009年 / 13卷
关键词
Acute HIV infection; Nucleic acid amplification tests; HIV RNA testing; Early detection of acute HIV infection;
D O I
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学科分类号
摘要
Acute/early HIV infection plays a critical role in onward HIV transmission. Detection of HIV infections during this period provides an important early opportunity to offer interventions which may prevent further transmission. In six US cities, persons with acute/early HIV infection were identified using either HIV RNA testing of pooled sera from persons screened HIV antibody negative or through clinical referral of persons with acute or early infections. Fifty-one cases were identified and 34 (68%) were enrolled into the study; 28 (82%) were acute infections and 6 (18%) were early infections. Of those enrolled, 13 (38%) were identified through HIV pooled testing of 7,633 HIV antibody negative sera and 21 (62%) through referral. Both strategies identified cases that would have been missed under current HIV testing and counseling protocols. Efforts to identify newly infected persons should target specific populations and geographic areas based on knowledge of the local epidemiology of incident infections.
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页码:1037 / 1045
页数:8
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