Strategies Used in the Detection of Acute/Early HIV Infections. The NIMH Multisite Acute HIV Infection Study: I

被引：23

作者：

Kerndt, Peter R. ^{[1
]}

Dubrow, Robert ^{[2
]}

Aynalem, Getahun ^{[1
]}

Mayer, Kenneth H. ^{[3
]}

Beckwith, Curt ^{[3
]}

Remien, Robert H. ^{[4
]}

Truong, Hong-Ha M. ^{[5
]}

Uniyal, Apurva ^{[1
]}

Chien, Michael ^{[1
]}

Brooks, Ronald A. ^{[6
]}

Vigil, Ofilio R. ^{[7
]}

Steward, Wayne T. ^{[5
]}

Merson, Michael ^{[8
]}

Rotheram-Borus, Mary Jane ^{[6
]}

Morin, Stephen F. ^{[5
]}

机构：

[1] Los Angeles Cty Dept Publ Hlth, Sexually Trasmitted Dis Program, Los Angeles, CA 90007 USA

[2] Yale Univ, Ctr Interdisciplinary Res AIDS, New Haven, CT USA

[3] Brown Univ, Providence, RI 02912 USA

[4] Columbia Univ, HIV Ctr Clin & Behav Studies, New York State Psychiat Inst, New York, NY USA

[5] Univ Calif San Francisco, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA

[6] Univ Calif Los Angeles, Ctr HIV Identificat Prevent & Treatment Serv, Los Angeles, CA USA

[7] Univ Calif San Diego, HIV Neurobehav Res Ctr, San Diego, CA 92103 USA

[8] Duke Univ, Durham, NC USA

来源：

AIDS AND BEHAVIOR | 2009年 / 13卷 / 06期

关键词：

Acute HIV infection; Nucleic acid amplification tests; HIV RNA testing; Early detection of acute HIV infection; UNITED-STATES; SEXUAL RISK; COITAL ACT; TRANSMISSION; DIAGNOSIS; OPPORTUNITIES; PREVENTION; RESISTANCE; BEHAVIOR; SPREAD;

D O I：

10.1007/s10461-009-9580-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Acute/early HIV infection plays a critical role in onward HIV transmission. Detection of HIV infections during this period provides an important early opportunity to offer interventions which may prevent further transmission. In six US cities, persons with acute/early HIV infection were identified using either HIV RNA testing of pooled sera from persons screened HIV antibody negative or through clinical referral of persons with acute or early infections. Fifty-one cases were identified and 34 (68%) were enrolled into the study; 28 (82%) were acute infections and 6 (18%) were early infections. Of those enrolled, 13 (38%) were identified through HIV pooled testing of 7,633 HIV antibody negative sera and 21 (62%) through referral. Both strategies identified cases that would have been missed under current HIV testing and counseling protocols. Efforts to identify newly infected persons should target specific populations and geographic areas based on knowledge of the local epidemiology of incident infections.

引用

页码：1037 / 1045

页数：9

共 50 条

[1] Strategies Used in the Detection of Acute/Early HIV Infections. The NIMH Multisite Acute HIV Infection Study: I
Peter R. Kerndt
Robert Dubrow
Getahun Aynalem
Kenneth H. Mayer
Curt Beckwith
Robert H. Remien
Hong-Ha M. Truong
Apurva Uniyal
Michael Chien
Ronald A. Brooks
Ofilio R. Vigil
Wayne T. Steward
Michael Merson
Mary Jane Rotheram-Borus
Stephen F. Morin
[J]. AIDS and Behavior, 2009, 13 : 1037 - 1045
[2] Psychiatric Context of Acute/Early HIV Infection. The NIMH Multisite Acute HIV Infection Study: IV
Atkinson, J. Hampton
Higgins, Jenny A.
Vigil, Ofilio
Dubrow, Robert
Remien, Robert H.
Steward, Wayne T.
Casey, Corinna Young
Sikkema, Kathleen J.
Correale, Jackie
Ake, Chris
McCutchan, J. Allen
Kerndt, Peter R.
Morin, Stephen F.
Grant, Igor
[J]. AIDS AND BEHAVIOR, 2009, 13 (06) : 1061 - 1067
[3] Psychiatric Context of Acute/Early HIV Infection. The NIMH Multisite Acute HIV Infection Study: IV
J. Hampton Atkinson
Jenny A. Higgins
Ofilio Vigil
Robert Dubrow
Robert H. Remien
Wayne T. Steward
Corinna Young Casey
Kathleen J. Sikkema
Jackie Correale
Chris Ake
J. Allen McCutchan
Peter R. Kerndt
Stephen F. Morin
Igor Grant
[J]. AIDS and Behavior, 2009, 13 : 1061 - 1067
[4] Lessons Learned about Behavioral Science and Acute/Early HIV Infection. The NIMH Multisite Acute HIV Infection Study: V
Kelly, Jeffrey A.
Morin, Stephen F.
Remien, Robert H.
Steward, Wayne T.
Higgins, Jenny A.
Seal, David W.
Dubrow, Robert
Atkinson, J. H.
Kerndt, Peter R.
Pinkerton, Steven D.
Mayer, Kenneth
Sikkema, Kathleen J.
[J]. AIDS AND BEHAVIOR, 2009, 13 (06) : 1068 - 1074
[5] Lessons Learned about Behavioral Science and Acute/Early HIV Infection. The NIMH Multisite Acute HIV Infection Study: V
Jeffrey A. Kelly
Stephen F. Morin
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J. H. Atkinson
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[J]. AIDS and Behavior, 2009, 13 : 1068 - 1074
[6] Behavior Change Following Diagnosis with Acute/Early HIV Infection—A Move to Serosorting with Other HIV-Infected Individuals. The NIMH Multisite Acute HIV Infection Study: III
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Mallory O. Johnson
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[J]. AIDS and Behavior, 2009, 13 : 1054 - 1060
[7] Behavior Change Following Diagnosis with Acute/Early HIV Infection-A Move to Serosorting with Other HIV-Infected Individuals. The NIMH Multisite Acute HIV Infection Study: III
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Sikkema, Kathleen J.
Truong, Hong-Ha M.
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Morin, Stephen F.
[J]. AIDS AND BEHAVIOR, 2009, 13 (06) : 1054 - 1060
[8] Lack of Understanding of Acute HIV Infection among Newly-Infected Persons-Implications for Prevention and Public Health: The NIMH Multisite Acute HIV Infection Study: II
Remien, Robert H.
Higgins, Jenny A.
Correale, Jackie
Bauermeister, Jose
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Bradley, Mark
Steward, Wayne T.
Seal, David W.
Sikkema, Kathleen J.
Kerndt, Peter R.
Mayer, Kenneth H.
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Casey, Corinna Young
Ehrhardt, Anke A.
Morin, Stephen F.
[J]. AIDS AND BEHAVIOR, 2009, 13 (06) : 1046 - 1053
[9] Use of Quantitative HIV RNA Detection for Early Diagnosis of HIV Infection in Infants and Acute HIV Infections in Alberta, Canada
Lee, Bonita E.
Plitt, Sabrina S.
Jayaraman, Gayatri C.
Chui, Linda
Singh, Ameeta E.
Preiksaitis, Jutta K.
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (02) : 502 - 505
[10] The Detection of Acute HIV Infection
Cohen, Myron S.
Gay, Cynthia L.
Busch, Michael P.
Hecht, Frederick M.
[J]. JOURNAL OF INFECTIOUS DISEASES, 2010, 202 : S270 - S277

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