Validation of a colorimetric method for determination of paracetamol in exhaled breath condensate

被引:0
|
作者
Fariba Pourkarim
Elaheh Rahimpour
Maryam Khoubnasabjafari
Vahid Jouyban-Gharamaleki
Afshin Gharakhani
Abolghasem Jouyban
机构
[1] Tabriz University of Medical Sciences,Pharmaceutical Analysis Research Center and Faculty of Pharmacy
[2] Tabriz University of Medical Sciences,Biotechnology Research Center
[3] Tabriz University of Medical Sciences,Food and Drug Safety Research Center
[4] Tabriz University of Medical Sciences,Tuberculosis and Lung Diseases Research Center
[5] Tabriz University of Medical Sciences,Liver and Gastrointestinal Diseases Research Center
[6] Tabriz University of Medical Sciences,Immunology Research Center
来源
Chemical Papers | 2021年 / 75卷
关键词
Paracetamol; Exhaled breath condensate; Redox reaction; Colorimetry;
D O I
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中图分类号
学科分类号
摘要
A redox reaction-based colorimetric method was validated for the qualitative assay and quantitative determination of paracetamol in exhaled breath condensate (EBC). Fe (III) and K3[Fe(CN)6] were used as colorimetric reagents in which paracetamol reduces Fe (III) to Fe (II) due to its reducing property. The produced Fe (II) is chelated with K3[Fe(CN)6] to form prussian blue colored product which can be detected by the naked eye in the range of 0.2–10.0 μg mL−1. The fully validated method was used for the determination of paracetamol in EBC of paracetamol poisoning individuals.
引用
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页码:2901 / 2906
页数:5
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