Validation of a colorimetric method for determination of paracetamol in exhaled breath condensate

被引：0

作者：

Fariba Pourkarim

Elaheh Rahimpour

Maryam Khoubnasabjafari

Vahid Jouyban-Gharamaleki

Afshin Gharakhani

Abolghasem Jouyban

机构：

[1] Tabriz University of Medical Sciences,Pharmaceutical Analysis Research Center and Faculty of Pharmacy

[2] Tabriz University of Medical Sciences,Biotechnology Research Center

[3] Tabriz University of Medical Sciences,Food and Drug Safety Research Center

[4] Tabriz University of Medical Sciences,Tuberculosis and Lung Diseases Research Center

[5] Tabriz University of Medical Sciences,Liver and Gastrointestinal Diseases Research Center

[6] Tabriz University of Medical Sciences,Immunology Research Center

来源：

Chemical Papers | 2021年 / 75卷

关键词：

Paracetamol; Exhaled breath condensate; Redox reaction; Colorimetry;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A redox reaction-based colorimetric method was validated for the qualitative assay and quantitative determination of paracetamol in exhaled breath condensate (EBC). Fe (III) and K3[Fe(CN)6] were used as colorimetric reagents in which paracetamol reduces Fe (III) to Fe (II) due to its reducing property. The produced Fe (II) is chelated with K3[Fe(CN)6] to form prussian blue colored product which can be detected by the naked eye in the range of 0.2–10.0 μg mL−1. The fully validated method was used for the determination of paracetamol in EBC of paracetamol poisoning individuals.

引用

页码：2901 / 2906

页数：5

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