FMNL3 FH2–actin structure gives insight into formin-mediated actin nucleation and elongation

被引：0
|
作者：
Morgan E Thompson
Ernest G Heimsath
Timothy J Gauvin
Henry N Higgs
F Jon Kull
机构：
[1] Geisel School of Medicine at Dartmouth,Department of Biochemistry
[2] Dartmouth College,Department of Chemistry
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Formins regulate actin nucleation and filament elongation through their conserved FH2 domain. The formin FMNL3 induces assembly of filopodia, and now the crystal structure of its FH2 domain in complex with actin, together with functional analyses, provides insight into formin's activities.
引用
收藏
页码：111 / 118
页数：7
相关论文
共 43 条
  • [41] Molecular Basis of Actin Nucleation Factor Cooperativity CRYSTAL STRUCTURE OF THE SPIR-1 KINASE NON-CATALYTIC C-LOBE DOMAIN (KIND).FORMIN-2 FORMIN SPIR INTERACTION MOTIF (FSI) COMPLEX
    Zeth, Kornelius
    Pechlivanis, Markos
    Samol, Annette
    Pleiser, Sandra
    Vonrhein, Clemens
    Kerkhoff, Eugen
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (35) : 30732 - 30739
  • [42] Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex
    Luan, Qing
    Liu, Su-Ling
    Helgeson, Luke A.
    Nolen, Brad J.
    EMBO JOURNAL, 2018, 37 (22):
  • [43] ARP2/3-Mediated Actin Nucleation Associated With Symbiosome Membrane Is Essential for the Development of Symbiosomes in Infected Cells of Medicago truncatula Root Nodules
    Gavrin, Aleksandr
    Jansen, Veerle
    Ivanov, Sergey
    Bisseling, Ton
    Fedorova, Elena
    MOLECULAR PLANT-MICROBE INTERACTIONS, 2015, 28 (05) : 605 - 614
12345