FMNL3 FH2–actin structure gives insight into formin-mediated actin nucleation and elongation

被引：0
|
作者：
Morgan E Thompson
Ernest G Heimsath
Timothy J Gauvin
Henry N Higgs
F Jon Kull
机构：
[1] Geisel School of Medicine at Dartmouth,Department of Biochemistry
[2] Dartmouth College,Department of Chemistry
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Formins regulate actin nucleation and filament elongation through their conserved FH2 domain. The formin FMNL3 induces assembly of filopodia, and now the crystal structure of its FH2 domain in complex with actin, together with functional analyses, provides insight into formin's activities.
引用
收藏
页码：111 / 118
页数：7
相关论文
共 43 条
  • [31] Nckipsd Coordinates Arp2/3 and Formin Nucleation of Actin Filaments in the Cell Cortex
    Cao, Luyan
    Yonis, Amina
    Vaghela, Malti
    Chugh, Priyamvada
    Bohec, Pierre
    Smith, Matt
    Lavoie, Genevieve
    Paluch, Ewa K.
    Roux, Philippe
    Jegou, Antoine G.
    Charras, Guillaume
    Romet-Lemonne, Guillaume
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 253A - 253A
  • [32] Dueling nucleation factors: Competition between formin and Arp2/3 complex for actin monomers
    Suarez, C.
    James, M. L.
    Sirotkin, V.
    Kovar, D. R.
    MOLECULAR BIOLOGY OF THE CELL, 2012, 23
  • [33] Caldesmon inhibits Arp2/3-mediated actin nucleation
    Yamakita, Y
    Oosawa, F
    Yamashiro, S
    Matsumura, F
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (20) : 17937 - 17944
  • [34] Lateral distribution of phosphatidylinositol 4,5-bisphosphate in membranes regulates formin- and ARP2/3-mediated actin nucleation
    Bucki, Robert
    Wang, Yu-Hsiu
    Yang, Changsong
    Kandy, Sreeja Kutti
    Fatunmbi, Ololade
    Bradley, Ryan
    Pogoda, Katarzyna
    Svitkina, Tatyana
    Radhakrishnan, Ravi
    Janmey, Paul A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (12) : 4704 - 4722
  • [35] Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility
    Skoble, J
    Auerbuch, V
    Goley, ED
    Welch, MD
    Portnoy, DA
    JOURNAL OF CELL BIOLOGY, 2001, 155 (01): : 89 - 100
  • [36] Identification of regions in ActA involved in arp2/3 complex-mediated actin nucleation.
    Skoble, J
    Portnoy, DA
    Welch, MD
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 158A - 158A
  • [37] Division of Labor Between Two Actin Nucleators-the Formin FH1 and the ARP2/3 Complex-in Arabidopsis Epidermal Cell Morphogenesis
    Cifrova, Petra
    Oulehlova, Denisa
    Kollarova, Eva
    Martinek, Jan
    Rosero, Amparo
    Zarsky, Viktor
    Schwarzerova, Katerina
    Cvrckova, Fatima
    FRONTIERS IN PLANT SCIENCE, 2020, 11
  • [38] Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions
    Egile, C
    Rouiller, I
    Xu, XP
    Volkmann, N
    Li, R
    Hanein, D
    PLOS BIOLOGY, 2005, 3 (11): : 1902 - 1909
  • [39] The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis
    King, Virginia L.
    Leclair, Nathan K.
    Coulter, Alyssa M.
    Campellone, Kenneth G.
    PLOS GENETICS, 2021, 17 (04):
  • [40] Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility
    Skoble, J
    Portnoy, DA
    Welch, MD
    JOURNAL OF CELL BIOLOGY, 2000, 150 (03): : 527 - 537
12345