Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles

被引：0
|
作者：
C. Radhika
A. Venkatesham
Manda Sarangapani
机构：
[1] RBVRR Women’s College of Pharmacy,University College of Pharmaceutical Sciences
[2] Kakatiya University,undefined
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
1,2,4-Triazole; Thiol; Antidepressant activity; Aroyl thiosemicarbazide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 5-aryl-1H-1,2,4-triazole-3-thiol (3) were synthesized. Alkylation of thiol group with N,N-dimethyl/diethyl/dicyclo hexyl-(2-chloro ethyl) amine gave compounds N,N-disubstituted-2-(5-aryl-1H-1,2,4-triazol-3-ylthio)ethanamine (4). These compounds were characterized on the basis of IR, 1H NMR, Mass spectral data, and elemental analysis. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice.
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页码：3509 / 3513
页数：4
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