Synthesis and cytotoxic activity of trinitromethyl derivatives of 1,3,5-triazine

被引：0

作者：

Bakharev V.V. ^{[1
]}

Gidaspov A.A. ^{[1
]}

Yakunina N.G. ^{[2
]}

Bulychev Yu.N. ^{[2
]}

机构：

[1] Samara State Technical University, Samara

[2] Science Research Institute of Experimental Tumor Diagnosis and Treatment, N. N. Blokhin Russian Oncological Scientific Center, Russian Academy of Medical Sciences, Moscow

来源：

Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 5期

关键词：

Cytotoxic Activity; Triazine; Human Tumor Cell Line; Compound VIII; Cyanuric Chloride;

D O I：

10.1007/s11094-008-0101-2

中图分类号：

学科分类号：

摘要：

New trinitromethyl derivatives of 1,3,5-triazine were synthesized with different substituents in positions 2 and 4. Data on the in vitro cytotoxic activity of the resulting compounds were obtained using a panel of 60 human tumor cell lines. The most active compounds were the 2,4-diamino-and 2-dimethylamino-4-azido derivatives. In terms of the general level of cytotoxicity, compounds of this series were more active than previously studied polynitromethyl derivatives of 1,3,5-triazine. © 2008 Springer Science+Business Media, Inc.

引用

页码：241 / 244

页数：3

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