Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

被引：103
|
作者：
Zhou, Chunhui [1 ]
Min, Jaeki [1 ]
Liu, Zhigang [1 ]
Young, Anne [1 ]
Deshazer, Heather [1 ]
Gao, Tian [1 ]
Chang, Young-Tae [1 ]
Kallenbach, Neville R. [1 ]
机构：
[1] NYU, Dept Chem, New York, NY 10003 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期
关键词：
cationic antimicrobial peptide mimetic; 1,3,5-triazine; membranolytic;
D O I：
10.1016/j.bmcl.2008.01.031
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1308 / 1311
页数：4
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