Statins and Renal Disease: Friend or Foe?

被引：0
|
作者：
Abhishek Deshmukh
Jawahar L. Mehta
机构：
[1] the University of Arkansas for Medical Sciences,Department of Medicine
[2] and the Central Arkansas Veterans Healthcare System,Cardiovascular Medicine
[3] University of Arkansas for Medical Sciences,undefined
来源：
Current Atherosclerosis Reports | 2011年 / 13卷
关键词：
Coronary heart disease; Chronic kidney disease; Dyslipidemia; Statins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of statins in the treatment and prevention of cardiovascular diseases, such as coronary artery disease, acute coronary syndromes, diabetes, or stroke, is well established. However, there are still some questions regarding the role of statins in patients with chronic kidney disease (CKD). Dyslipidemia is a known cardiovascular risk factor in individuals without CKD. In these patients, however, the relation of dyslipidemia to cardiovascular risk is complex, and the underlying pathobiological mechanisms are complex. Statins have proven to be highly effective in patients with initial stages of CKD; however, their effects in patients with advanced-stage CKD have been neutral despite a low-density lipoprotein cholesterol–lowering effect. In this review, we summarize the findings of the recent clinical trials of statins in renal disease and make recommendations for our patients.
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页码：57 / 63
页数：6
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