Statins and the Kidney: Friend or Foe?

被引：12
|
作者：
Honore, Patrick M. [1 ]
Jacobs, Rita [1 ]
Hendrickx, Inne [1 ]
De Waele, Elisabeth [1 ]
Van Gorp, Viola [1 ]
De Regt, Jouke [1 ]
Spapen, Herbert D. [1 ]
机构：
[1] Vrije Univ Brussel, Univ Ziekenhuis Brussel, ICU Dept, Brussels, Belgium
来源：
BLOOD PURIFICATION | 2017年 / 43卷 / 1-3期
关键词：
Statins; Acute kidney injury; Chronic kidney disease; Rhabdomyolysis; Contrast-induced nephropathy; Cardiorenal syndrome; End-stage renal disease; LOWERING LDL CHOLESTEROL; PLACEBO-CONTROLLED TRIAL; STAGE RENAL-DISEASE; CARDIAC-SURGERY; INJURY; THERAPY; ATORVASTATIN; METAANALYSIS; RISK; ROSUVASTATIN;
D O I：
10.1159/000453577
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to controlling cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabilizing activity. Along this line, statins may also exert acute and long-term effects on renal function. We present a narrative literature review that summarizes arguments in favour or against the preventive and/or therapeutic use of statins in kidney-related diseases or complications. We also highlight the ongoing controversy regarding statin therapy in chronic and endstage kidney disease. (C) 2016 S. Karger AG, Basel
引用
收藏
页码：91 / 96
页数：6
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