Statins and Renal Disease: Friend or Foe?

被引：0
|
作者：
Deshmukh, Abhishek [2 ,3 ]
Mehta, Jawahar L. [1 ,2 ,3 ]
机构：
[1] Univ Arkansas Med Sci, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA
[3] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2011年 / 13卷 / 01期
关键词：
Coronary heart disease; Chronic kidney disease; Dyslipidemia; Statins; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR EVENTS; UNITED-STATES; METAANALYSIS; ROSUVASTATIN; ATORVASTATIN; PARTICIPANTS; PRAVASTATIN; PREVENTION; MORTALITY;
D O I：
10.1007/s11883-010-0140-5
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The role of statins in the treatment and prevention of cardiovascular diseases, such as coronary artery disease, acute coronary syndromes, diabetes, or stroke, is well established. However, there are still some questions regarding the role of statins in patients with chronic kidney disease (CKD). Dyslipidemia is a known cardiovascular risk factor in individuals without CKD. In these patients, however, the relation of dyslipidemia to cardiovascular risk is complex, and the underlying pathobiological mechanisms are complex. Statins have proven to be highly effective in patients with initial stages of CKD; however, their effects in patients with advanced-stage CKD have been neutral despite a low-density lipoprotein cholesterol-lowering effect. In this review, we summarize the findings of the recent clinical trials of statins in renal disease and make recommendations for our patients.
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收藏
页码：57 / 63
页数：7
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