Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

被引：0

作者：

Manuel A Friese

Karen B Jakobsen

Lone Friis

Ruth Etzensperger

Matthew J Craner

Róisín M McMahon

Lise T Jensen

Véronique Huygelen

E Yvonne Jones

John I Bell

Lars Fugger

机构：

[1] Medical Research Council Human Immunology Unit,Department of Clinical Neurology

[2] Weatherall Institute of Molecular Medicine,Division of Structural Biology

[3] John Radcliffe Hospital,undefined

[4] University of Oxford,undefined

[5] Weatherall Institute of Molecular Medicine,undefined

[6] John Radcliffe Hospital,undefined

[7] University of Oxford,undefined

[8] Institut für Neuroimmunologie und Klinische MS-Forschung,undefined

[9] Zentrum für Molekulare Neurobiologie,undefined

[10] Universitätsklinikum Hamburg-Eppendorf,undefined

[11] The Henry Wellcome Building for Genomic Medicine,undefined

[12] University of Oxford,undefined

[13] Clinical Institute,undefined

[14] Aarhus University Hospital,undefined

[15] Skejby Sygehus,undefined

[16] Office of the Regius Professor of Medicine,undefined

[17] The Richard Doll Building,undefined

[18] Roosevelt Drive,undefined

[19] University of Oxford,undefined

来源：

Nature Medicine | 2008年 / 14卷

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摘要：

Although major histocompatibility complex (MHC) class II alleles and CD4+ T cells have been implicated in multiple sclerosis, Friese et al. provide here the first direct evidence incriminating MHC class I genes and CD8+ T cells in the pathogenesis of this autoimmune disorder (pages 1150–1151).

引用

页码：1227 / 1235

页数：8

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