Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

被引：0

作者：

Manuel A Friese

Karen B Jakobsen

Lone Friis

Ruth Etzensperger

Matthew J Craner

Róisín M McMahon

Lise T Jensen

Véronique Huygelen

E Yvonne Jones

John I Bell

Lars Fugger

机构：

[1] Medical Research Council Human Immunology Unit,Department of Clinical Neurology

[2] Weatherall Institute of Molecular Medicine,Division of Structural Biology

[3] John Radcliffe Hospital,undefined

[4] University of Oxford,undefined

[5] Weatherall Institute of Molecular Medicine,undefined

[6] John Radcliffe Hospital,undefined

[7] University of Oxford,undefined

[8] Institut für Neuroimmunologie und Klinische MS-Forschung,undefined

[9] Zentrum für Molekulare Neurobiologie,undefined

[10] Universitätsklinikum Hamburg-Eppendorf,undefined

[11] The Henry Wellcome Building for Genomic Medicine,undefined

[12] University of Oxford,undefined

[13] Clinical Institute,undefined

[14] Aarhus University Hospital,undefined

[15] Skejby Sygehus,undefined

[16] Office of the Regius Professor of Medicine,undefined

[17] The Richard Doll Building,undefined

[18] Roosevelt Drive,undefined

[19] University of Oxford,undefined

来源：

Nature Medicine | 2008年 / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Although major histocompatibility complex (MHC) class II alleles and CD4+ T cells have been implicated in multiple sclerosis, Friese et al. provide here the first direct evidence incriminating MHC class I genes and CD8+ T cells in the pathogenesis of this autoimmune disorder (pages 1150–1151).

引用

页码：1227 / 1235

页数：8

共 50 条

[21] Detection of myelin-reactive CD8+ T cells in multiple sclerosis
Sabatino, J. J., Jr.
Wilson, M. R.
Calabresi, P. A.
Hauser, S. L.
Schneck, J. P.
Zamvil, S. S.
MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 508 - 508
[22] HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity
Keane, Niamh M.
Pavlos, Rebecca K.
McKinnon, Elizabeth
Lucas, Andrew
Rive, Craig
Blyth, Christopher C.
Dunn, David
Lucas, Michaela
Mallal, Simon
Phillips, Elizabeth
AIDS, 2014, 28 (13) : 1891 - 1901
[23] Tissue-resident CD8+ memory T cells in multiple sclerosis
Hohlfeld, Reinhard
Beltran, Eduardo
Gerdes, Lisa Ann
Dornmair, Klaus
BRAIN, 2021, 144
[24] Increased CD8+ central memory T cells in patients with multiple sclerosis
Liu, Guang-Zhi
Fang, Li-Bo
Hjelmstrom, Peter
Gao, Xu-Guang
MULTIPLE SCLEROSIS JOURNAL, 2007, 13 (02) : 149 - 155
[25] CLONAL DOMINANCE OF CD8+ T-CELLS IN MULTIPLE-SCLEROSIS
MONTEIRO, J
HINGORANI, R
PERGOLIZZI, R
APATOFF, B
GREGERSEN, PK
T-CELL RECEPTOR USE IN HUMAN AUTOIMMUNE DISEASES, 1995, 756 : 310 - 312
[26] OLIGOCLONAL EXPANSION OF CD8+ T-CELLS IN MULTIPLE-SCLEROSIS
MONTEIRO, J
HINGDRANI, R
PERGOLIZZI, R
APATOFF, BR
GREGERSON, PK
NEUROLOGY, 1994, 44 (04) : A147 - A147
[27] Autoreactive CD8+ T-cells are highly dependent on CD8 for activation and as such targeting CD8 is an effective way of blocking autoreactive CD8+ T-cell activation
Wooldridge, Linda
Morgan, David
Pearson, James Alexander
Gras, Stephanie
van den Berg, Hugo
Lissina, Anya
Llewellyn-Lacey, Sian
Willis, Mark
Dockree, Tamsin
McLaren, James E.
Ekeruche-Makinde, Julia
Gostick, Emma
Robertson, Neil
Rossjohn, Jamie
Burrows, Scott R.
Price, David
Wong, Susan
Peakman, Mark
Skowera, Ania
Clement, Matthew
JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
[28] MHC class II molecules can play a role in the selection of class I restricted β-cell autoreactive CD8 T cells
Marron, M
Holl, TM
Grasser, R
Serreze, D
DIABETES, 2001, 50 : A262 - A263
[29] Interferon-β therapy reduces autoreactive CD4+ and CD8+ memory T cell responses in multiple sclerosis
不详
IMMUNOBIOLOGY, 2005, 210 (6-8) : 415 - 416
[30] High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
Crawford, MP
Yan, SX
Ortega, SB
Mehta, RS
Hewitt, RE
Price, DA
Stastny, P
Douek, DC
Koup, RA
Racke, MK
Karandikar, NJ
BLOOD, 2004, 103 (11) : 4222 - 4231

← 1 2 3 4 5 →