Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

被引：0

作者：

Manuel A Friese

Karen B Jakobsen

Lone Friis

Ruth Etzensperger

Matthew J Craner

Róisín M McMahon

Lise T Jensen

Véronique Huygelen

E Yvonne Jones

John I Bell

Lars Fugger

机构：

[1] Medical Research Council Human Immunology Unit,Department of Clinical Neurology

[2] Weatherall Institute of Molecular Medicine,Division of Structural Biology

[3] John Radcliffe Hospital,undefined

[4] University of Oxford,undefined

[5] Weatherall Institute of Molecular Medicine,undefined

[6] John Radcliffe Hospital,undefined

[7] University of Oxford,undefined

[8] Institut für Neuroimmunologie und Klinische MS-Forschung,undefined

[9] Zentrum für Molekulare Neurobiologie,undefined

[10] Universitätsklinikum Hamburg-Eppendorf,undefined

[11] The Henry Wellcome Building for Genomic Medicine,undefined

[12] University of Oxford,undefined

[13] Clinical Institute,undefined

[14] Aarhus University Hospital,undefined

[15] Skejby Sygehus,undefined

[16] Office of the Regius Professor of Medicine,undefined

[17] The Richard Doll Building,undefined

[18] Roosevelt Drive,undefined

[19] University of Oxford,undefined

来源：

Nature Medicine | 2008年 / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Although major histocompatibility complex (MHC) class II alleles and CD4+ T cells have been implicated in multiple sclerosis, Friese et al. provide here the first direct evidence incriminating MHC class I genes and CD8+ T cells in the pathogenesis of this autoimmune disorder (pages 1150–1151).

引用

页码：1227 / 1235

页数：8

共 50 条

[1] Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
Friese, Manuel A.
Jakobsen, Karen B.
Friis, Lone
Etzensperger, Ruth
Craner, Matthew J.
McMahon, Roisin M.
Jensen, Lise T.
Huygelen, Veronique
Jones, E. Yvonne
Bell, John I.
Fugger, Lars
NATURE MEDICINE, 2008, 14 (11) : 1227 - 1235
[2] Autoreactive Regulatory CD8+ T Cells in Multiple Sclerosis
Baughman, Ethan
Mendoza, Jason
Frohman, Elliot
Karandikar, Nitin
CLINICAL IMMUNOLOGY, 2010, 135 : S44 - S45
[3] HLA class I antigens modulate activity of CD8+ T cells in multiple sclerosis
Nature Clinical Practice Neurology, 2009, 5 (2): : 64 - 65
[4] Autoreactive CD8+ T cells in multiple sclerosis:: a new target for therapy?
Friese, MA
Fugger, L
BRAIN, 2005, 128 : 1747 - 1763
[5] CD8+ T cells in multiple sclerosis
Denic, Aleksandar
Wootla, Bharath
Rodriguez, Moses
EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (09) : 1053 - 1066
[6] Involvement of CD8+ T Cells in Multiple Sclerosis
Salou, Marion
Nicol, Bryan
Garcia, Alexandra
Laplaud, David-Axel
FRONTIERS IN IMMUNOLOGY, 2015, 6
[7] Pathogenic CD8+ T Cells in Multiple Sclerosis
Friese, Manuel A.
Fugger, Lars
ANNALS OF NEUROLOGY, 2009, 66 (02) : 132 - 141
[8] Oligoclonality of CD8+ T cells in multiple sclerosis
Monteiro, J
Hingorani, R
Peroglizzi, R
Apatoff, B
Gregersen, PK
AUTOIMMUNITY, 1996, 23 (02) : 127 - 138
[9] Are HLA-E Restricted CD8+ T Cells Functionally Altered in Multiple Sclerosis?
Pannemans, Kim
Goris, An
Dobosi, Rita
Dubois, Benedicte
van Wijmeersch, Bart
Stinissen, P.
Hellings, Niels
CLINICAL IMMUNOLOGY, 2009, 131 : S125 - S125
[10] Immune regulation of multiple sclerosis by CD8+ T cells
Sushmita Sinha
Farah R. Itani
Nitin J. Karandikar
Immunologic Research, 2014, 59 : 254 - 265

← 1 2 3 4 5 →