Synthesis of [14C] quincetone

被引：0

作者：

Li Yu-guo

Huang Xuan

Liu Riu-li

Li Qing-nuan

Zhang Xiao-dong

Li Wen-xin

机构：

[1] Laboratory of Nanoscale Biomedicine,

[2] Shanghai Institute of Applied Physics,undefined

[3] Chinese Academy of Sciences,undefined

[4] Laboratory of Nanoscale Biomedicine,undefined

[5] Shanghai Institute of Applied Physics,undefined

[6] Chinese Academy of Sciences,undefined

[7] Laboratory of Nanoscale Biomedicine,undefined

[8] Shanghai Institute of Applied Physics,undefined

[9] Chinese Academy of Sciences,undefined

[10] Laboratory of Nanoscale Biomedicine,undefined

[11] Shanghai Institute of Applied Physics,undefined

[12] Chinese Academy of Sciences,undefined

[13] Shanghai Jiaotong University of Chinese,undefined

[14] Laboratory of Nanoscale Biomedicine,undefined

[15] Shanghai Institute of Applied Physics,undefined

[16] Chinese Academy of Sciences,undefined

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2005年 / 265卷 / 1期

关键词：

Physical Chemistry; Bone Marrow; Reaction Time; Inorganic Chemistry; Fullerene;

D O I：

10.1007/s10967-005-0802-x

中图分类号：

学科分类号：

摘要：

The water-soluble fullerene derivative C60(OH)x was radiolabeled with 67GaCl3. The labeling yields were determined by radio-PLC. The effects of pH, reaction time, temperature and the amount of C60(OH)x on the labeling yields were studied. The stability of 67Ga-C60(OH)x was also examined. The results showed that the labeling yields could reach 97% under the best labeling conditions and the radiochemical purity of 67Ga-C60(OH)x solution kept at 37 °C remained at 88% after 212 hours. The biodistribution studies of 67Ga-C60(OH)x in mice showed a high localization of 67Ga-C60(OH)x in the bone marrow, bone, liver and spleen with slow clearance and a negligible accumulation in the blood. These data suggest that the water-soluble C60(OH)x, having the same properties as microcolloids, may be used as a carrier of drug system for lymphatic targeting.

引用

页码：127 / 131

页数：4

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